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  Differential tinnitus-related neuroplastic alterations of cortical thickness and surface area

Meyer, M., Neff, P., Liem, F., Kleinjung, T., Weidt, S., Langguth, B., et al. (2016). Differential tinnitus-related neuroplastic alterations of cortical thickness and surface area. Hearing Research, 342, 1-12. doi:10.1016/j.heares.2016.08.016.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-18A0-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-19FD-5
Genre: Journal Article

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 Creators:
Meyer, Martin1, 2, 3, Author
Neff, Patrick1, 2, 4, Author
Liem, Franz5, Author              
Kleinjung, Tobias6, Author
Weidt, Steffi7, Author
Langguth, Berthold8, 9, Author
Schecklmann, Martin8, 9, Author
Affiliations:
1Neuroplasticity and Learning of the Healthy Aging Brain, Department of Psychology, University of Zurich, Switzerland, ou_persistent22              
2University Research Priority Program “Dynamics of Healthy Aging”, University of Zurich, Switzerland, ou_persistent22              
3Cognitive Psychology Unit (CPU), University of Klagenfurt, Austria, ou_persistent22              
4Institute for Computer Music and Sound Technology (ICST), University of Arts Zurich, Switzerland, ou_persistent22              
5Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
6Department of Otorhinolaryngology, University Hospital Zurich, Switzerland, ou_persistent22              
7Department of Psychiatry and Psychotherapy, University Hospital Zurich, Switzerland, ou_persistent22              
8Department for Psychiatry and Psychotherapy, University of Regensburg, Germany, ou_persistent22              
9Multidisciplinary Tinnitus Clinic at the University of Regensburg, Germany, ou_persistent22              

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Free keywords: Tinnitus; Surface-based morphometry; Neuroanatomy; Cortical thickness; Cortical surface area
 Abstract: Structural neuroimaging techniques have been used to identify cortical and subcortical regions constituting the neuroarchitecture of tinnitus. One recent investigation used voxel-based morphometry (VBM) to analyze a sample of tinnitus patients (TI, n = 257) (Schecklmann et al., 2013). A negative relationship between individual distress and cortical volume (CV) in bilateral auditory regions was observed. However, CV has meanwhile been identified as a neuroanatomical measurement that confounds genetically distinct neuroanatomical traits, namely cortical thickness (CT) and cortical surface area (CSA). We performed a re-analysis of the identical sample using the automated FreeSurfer surface-based morphometry (SBM) approach (Fischl, 2012). First, we replicated the negative correlation between tinnitus distress and bilateral supratemporal gray matter volume. Second, we observed a negative correlation for CSA in the left periauditory cortex and anterior insula. Furthermore, we noted a positive correlation between tinnitus duration and CT in the left periauditory cortex as well as a negative correlation in the subcallosal anterior cingulate, a region collated to the serotonergic circuit and germane to inhibitory functions. In short, the results elucidate differential neuroanatomical alterations of CSA and CT for the two independent tinnitus-related psychological traits distress and duration. Beyond this, the study provides further evidence for the distinction and specific susceptibility of CSA and CT within the context of neuroplasticity of the human brain.

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Language(s): eng - English
 Dates: 2016-08-262015-12-212016-08-312016-09-232016-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.heares.2016.08.016
PMID: 27671157
Other: Epub 2016
 Degree: -

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Title: Hearing Research
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 342 Sequence Number: - Start / End Page: 1 - 12 Identifier: ISSN: 0378-5955
CoNE: /journals/resource/954925527845