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  Transcranial alternating current stimulation at beta frequency: Lack of immediate effects on excitation and interhemispheric inhibition of the human motor cortex

Rjosk, V., Kaminski, E., Hoff, M., Gundlach, C., Villringer, A., Sehm, B., et al. (2016). Transcranial alternating current stimulation at beta frequency: Lack of immediate effects on excitation and interhemispheric inhibition of the human motor cortex. Frontiers in Human Neuroscience, 10: 560. doi:10.3389/fnhum.2016.00560.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-191D-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1E7B-3
Genre: Journal Article

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 Creators:
Rjosk, Viola1, Author              
Kaminski, Elisabeth1, Author              
Hoff, Maike1, Author              
Gundlach, Christopher1, 2, Author              
Villringer, Arno1, 3, Author              
Sehm, Bernhard1, Author              
Ragert, Patrick1, 4, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Institute of Psychology, University of Leipzig, Germany, ou_persistent22              
3Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
4Institute of General Kinesiology and Athletics Training, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Transcranial alternating current stimulation (tACS); Interhemispheric inhibition (IHI); Transcranial magnetic stimulation (TMS); Motor cortical excitability; Neuroplasticity
 Abstract: Transcranial alternating current stimulation (tACS) is a form of noninvasive brain stimulation and is capable of influencing brain oscillations and cortical networks. In humans, the endogenous oscillation frequency in sensorimotor areas peaks at 20 Hz. This beta-band typically occurs during maintenance of tonic motor output and seems to play a role in interhemispheric coordination of movements. Previous studies showed that tACS applied in specific frequency bands over primary motor cortex (M1) or the visual cortex modulates cortical excitability within the stimulated hemisphere. However, the particular impact remains controversial because effects of tACS were shown to be frequency, duration and location specific. Furthermore, the potential of tACS to modulate cortical interhemispheric processing, like interhemispheric inhibition (IHI), remains elusive. Transcranial magnetic stimulation (TMS) is a noninvasive and well-tolerated method of directly activating neurons in superficial areas of the human brain and thereby a useful tool for evaluating the functional state of motor pathways. The aim of the present study was to elucidate the immediate effect of 10 min tACS in the β-frequency band (20 Hz) over left M1 on IHI between M1s in 19 young, healthy, right-handed participants. A series of TMS measurements (motor evoked potential (MEP) size, resting motor threshold (RMT), IHI from left to right M1 and vice versa) was performed before and immediately after tACS or sham using a double-blinded, cross-over design. We did not find any significant tACS-induced modulations of intracortical excitation (as assessed by MEP size and RMT) and/or IHI. These results indicate that 10 min of 20 Hz tACS over left M1 seems incapable of modulating immediate brain activity or inhibition. Further studies are needed to elucidate potential aftereffects of 20 Hz tACS as well as frequency-specific effects of tACS on intracortical excitation and IHI.

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Language(s): eng - English
 Dates: 2016-07-272016-10-212016-11-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnhum.2016.00560
PMID: 27857687
PMC: PMC5093129
Other: eCollection 2016
 Degree: -

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 10 Sequence Number: 560 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161