Ratiometric detection of oligonucleotide stoichiometry on multifunctional gold 
nanoparticles by whispering gallery mode biosensing

Wu, F. C.; Wu, Y.; Niu, Z.; Vollmer, F.

doi:10.1039/c5an00179j

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Ratiometric detection of oligonucleotide stoichiometry on multifunctional gold nanoparticles by whispering gallery mode biosensing

Wu, F. C., Wu, Y., Niu, Z., & Vollmer, F. (2015). Ratiometric detection of oligonucleotide stoichiometry on multifunctional gold nanoparticles by whispering gallery mode biosensing. ANALYST, 140(9), 2969-2972. doi:10.1039/c5an00179j.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-6456-3 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002D-6457-1

Genre: Journal Article

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Creators:
Wu, F. C.¹, Author
Wu, Y.², Author
Niu, Z.², Author
Vollmer, F.¹, Author

Affiliations:
1Vollmer Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society, ou_2364719
2external, ou_persistent22

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Free keywords: LABEL-FREE MICROCAVITY; DNA DETECTION; SENSITIVITYChemistry;

Abstract: A label-free method is developed to ratiometrically determine the stoichiometry of oligonucleotides attached to the surface of gold nanoparticle (GNP) by whispering gallery mode biosensing. Utilizing this scheme, it is furthermore shown that the stoichiometric ratio of GNP attached oligonucleotide species can be controlled by varying the concentration ratio of thiolated oligonucleotides that are used to modify the GNP.

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Language(s): eng - English

Dates: Date issued: 2015

Publication Status: Issued

Pages: 4

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Table of Contents: -

Rev. Type: -

Identifiers: ISI: 000353154400006
DOI: 10.1039/c5an00179j

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Title: ANALYST

Source Genre: Journal

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Publ. Info: THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND : ROYAL SOC CHEMISTRY

Pages: - Volume / Issue: 140 (9) Sequence Number: - Start / End Page: 2969 - 2972 Identifier: ISSN: 0003-2654