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  Optimizing detection limits in whispering gallery mode biosensing

Foreman, M. R., Jin, W.-L., & Vollmer, F. (2014). Optimizing detection limits in whispering gallery mode biosensing. OPTICS EXPRESS, 22(5), 5491-5511. doi:10.1364/OE.22.005491.

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 Urheber:
Foreman, Matthew R.1, Autor           
Jin, Wei-Liang2, Autor
Vollmer, Frank1, Autor           
Affiliations:
1Vollmer Research Group, Research Groups, Max Planck Institute for the Science of Light, Max Planck Society, ou_2364719              
2external, ou_persistent22              

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Schlagwörter: OPTICAL MICROSPHERE RESONATORS; LABEL-FREE DETECTION; NANOPARTICLE DETECTION; MICROCAVITIES; SHIFT; RESONANCE; MOLECULES; SENSOROptics;
 Zusammenfassung: A theoretical analysis of detection limits in swept-frequency whispering gallery mode biosensing modalities is presented based on application of the Cramer-Rao lower bound. Measurement acuity factors are derived assuming the presence of uncoloured and 1/f Gaussian technical noise. Frequency fluctuations, for example arising from laser jitter or thermorefractive noise, are also considered. Determination of acuity factors for arbitrary coloured noise by means of the asymptotic Fisher information matrix is highlighted. Quantification and comparison of detection sensitivity for both resonance shift and broadening sensing modalities are subsequently given. Optimal cavity and coupling geometries are furthermore identified, whereby it is found that slightly under-coupled cavities outperform critically and over coupled ones. (C) 2014 Optical Society of America

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Sprache(n): eng - English
 Datum: 2014
 Publikationsstatus: Erschienen
 Seiten: 21
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000333579200106
DOI: 10.1364/OE.22.005491
 Art des Abschluß: -

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Titel: OPTICS EXPRESS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA : OPTICAL SOC AMER
Seiten: - Band / Heft: 22 (5) Artikelnummer: - Start- / Endseite: 5491 - 5511 Identifikator: ISSN: 1094-4087