English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Cobalt cross-linked redox-responsive PEG hydrogels: from viscoelastic liquids to elastic solids

Wegner, S., Schenk, F. C., Witzel, S., Bialas, F., & Spatz, J. P. (2016). Cobalt cross-linked redox-responsive PEG hydrogels: from viscoelastic liquids to elastic solids. Macromolecules, 49(11), 4229-4235. doi:10.1021/acs.macromol.6b00574.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-1C04-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-7E3C-5
Genre: Journal Article

Files

show Files
hide Files
:
Makromol_49_2016_4229.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
Makromol_49_2016_4229.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
Makromol_49_2016_4229_Suppl.pdf (Supplementary material), 534KB
 
File Permalink:
-
Name:
Makromol_49_2016_4229_Suppl.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Description:
-
Description:
-

Creators

show
hide
 Creators:
Wegner, Seraphine1, 2, Author              
Schenk, Franziska C.1, 2, Author              
Witzel, Sina, Author
Bialas, Friedrich, Author
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: We describe cobalt cross-linked redox-responsive 4-arm histidine-modified PEG (4A-PEG-His) hydrogels, which can be switched from self-healing viscoelastic liquids to form stable elastic solids through a simple oxidation step from Co2+ to Co3+. The dramatic change in gel properties is quantified in rheological measurements and is associated with the altered ligand exchange rate of the cross-linking cobalt ions. While Co2+ forms kinetically labile coordination bonds with low thermodynamic stability, Co3+ forms kinetically inert and highly stable coordination bonds. Unlike the Co2+ cross-linked hydrogels, the Co3+ cross-linked hydrogels do not dissolve in buffer and swell overtime, where they remain intact longer with increasing gel connectivity, increasing polymer concentration and decreasing temperature. Remarkably, these gels can even resist the strong chelator EDTA and withstand both low and high pH due to the low ligand exchange rates in the primary coordination sphere. Overall, the Co2+/3+ redox pair provides an attractive platform to produce redox-responsive materials with big deviations in mechanical and chemical properties.

Details

show
hide
Language(s): eng - English
 Dates: 2016-06-032016
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1021/acs.macromol.6b00574
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Macromolecules
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : American Chemical Society
Pages: - Volume / Issue: 49 (11) Sequence Number: - Start / End Page: 4229 - 4235 Identifier: ISSN: 0024-9297
CoNE: https://pure.mpg.de/cone/journals/resource/954925421108