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  Nanoscale and mechanical properties of the physiological cell–ECM microenvironment

Young, J. L., Holle, A. W., & Spatz, J. P. (2016). Nanoscale and mechanical properties of the physiological cell–ECM microenvironment. Experimental Cell Research, 343(1), 3-6. doi:10.1016/j.yexcr.2015.10.037.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-F210-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-5E95-8
Genre: Journal Article

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ExpCellRes_343_2016_3.pdf (Any fulltext), 434KB
 
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 Creators:
Young, Jennifer L.1, 2, Author              
Holle, Andrew W.1, 2, Author              
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: Extracellular matrix; Nanoscale; Stiffness; Topography; Ligands
 Abstract: Studying biological processes in vitro requires faithful and successful reconstitution of the in vivo extracellular matrix (ECM) microenvironment. However, the physiological basis behind in vitro studies is often forgotten or ignored. A number of diverse cell-ECM interactions have been characterized throughout the body and in disease, reflecting the heterogeneous nature of cell niches. Recently, a greater emphasis has been placed on characterizing both the chemical and physical characteristics of the ECM and subsequently mimicking these properties in the lab. Herein, we describe physiological measurement techniques and reported values for the three main physical aspects of the ECM: tissue stiffness, topography, and ligand presentation.

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Language(s): eng - English
 Dates: 2016-09-262016-10-292016-10-302016-04-10
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Experimental Cell Research
  Other : Exp. Cell Res.
Source Genre: Journal
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Publ. Info: San Diego, CA : Academic Press
Pages: - Volume / Issue: 343 (1) Sequence Number: - Start / End Page: 3 - 6 Identifier: ISSN: 0014-4827
CoNE: https://pure.mpg.de/cone/journals/resource/954922645016