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  Segregation versus colocalization: orthogonally functionalized binary micropatterned substrates regulate the molecular distribution in focal adhesions

Guasch, J., Conings, B., Neubauer, S., Rechenmacher, F., Ende, K., Rolli, C. G., et al. (2015). Segregation versus colocalization: orthogonally functionalized binary micropatterned substrates regulate the molecular distribution in focal adhesions. Advanced Materials, 27(25), 3737-3747. doi:10.1002/adma.201500900.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-2C9C-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-6014-E
Genre: Journal Article

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http://onlinelibrary.wiley.com/doi/10.1002/adma.201500900/epdf (Any fulltext)
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 Creators:
Guasch, Judit1, 2, Author           
Conings, Bert, Author
Neubauer, Stefanie, Author
Rechenmacher, Florian, Author
Ende, Karen, Author
Rolli, Claudio Gavino, Author
Kappel, Christian, Author
Schaufler, Viktoria, Author
Micoulet, Alexandre1, 2, Author           
Kessler, Horst, Author
Boyen, Hans-Gerd, Author
Cavalcanti-Adam, Elisabetta Ada1, 2, Author           
Spatz, Joachim P.1, 2, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: biomimetics; cell adhesion and migration; integrins; micropatterns; orthogonal functionalization
 Abstract: Orthogonally functionalized binary micropatterned substrates are produced using a novel protocol. The use of adequate peptido-mimetics enables an unprecedented segregation of purified αvβ3 and α5β1 integrins in adjacent microislands and evidences the preference of U2OS cells to colocalize such receptors. Moreover, this tendency can be altered by varying the geometry and composition of the micropatterns.

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Language(s): eng - English
 Dates: 2015-04-052015-02-212015-05-152015-07-01
 Publication Status: Issued
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/adma.201500900
URI: https://www.ncbi.nlm.nih.gov/pubmed/25981929
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Title: Advanced Materials
  Other : Adv. Mater.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 27 (25) Sequence Number: - Start / End Page: 3737 - 3747 Identifier: ISSN: 0935-9648
CoNE: https://pure.mpg.de/cone/journals/resource/954925570855