English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation

Wei, Q., Pohl, T. M. L., Seckinger, A., Spatz, J. P., & Cavalcanti-Adam, E. A. (2015). Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation. Beilstein Journal of Organic Chemistry, 11, 773-783. doi:10.3762/bjoc.11.87.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-81D8-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-7C6B-F
Genre: Journal Article

Files

show Files
hide Files
:
BeilsteinJOrgChem_13_2015_773.pdf (Any fulltext), 6MB
 
File Permalink:
-
Name:
BeilsteinJOrgChem_13_2015_773.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Locator:
https://dx.doi.org/10.3762/bjoc.11.87 (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Wei, Qiang1, 2, Author              
Pohl, Theresa M. L.1, Author              
Seckinger, Anja, Author
Spatz, Joachim P.1, 2, Author              
Cavalcanti-Adam, Elisabetta Ada1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

Content

show
hide
Free keywords: biomaterials; growth factor; integrin; osteodifferentiation; stem cells
 Abstract: Stem cells respond to the microenvironment (niche) they are located in. Under natural conditions, the extracellular matrix (ECM) is the essential component the in stem cell niche, in which both integrin ligands and growth factors are important regulators to directly or indirectly modulate the cell behavior. In this review, we summarize the current knowledge about the potential of integrin ligands and growth factors to induce osteogenic differentiation of stem cells, and discuss the signaling pathways that are initiated by both individual and cooperative parameters. The joint effect of integrin ligands and growth factors is highlighted as the multivalent interactions for bone therapy.

Details

show
hide
Language(s): eng - English
 Dates: 2015-03-262015-05-072015-05-132015-05-13
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Beilstein Journal of Organic Chemistry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Frankfurt, Germany : Beilstein-Institut
Pages: - Volume / Issue: 11 Sequence Number: - Start / End Page: 773 - 783 Identifier: ISSN: 1860-5397
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000021310