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  PEG-based antigen-presenting cell surrogates for immunological applications

Platzman, I., Kannenberg, G., Janiesch, J.-W., Matic, J., & Spatz, J. P. (2015). PEG-based antigen-presenting cell surrogates for immunological applications. In X. Chen, & H. Fuchs (Eds.), Soft Matter Nanotechnology: From Structure to Function (pp. 187-215). Weinheim: Wiley-VCH. doi:10.1002/9783527682157.ch07.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-2C78-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-7DC3-1
Genre: Book Chapter

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Chen_2015_Soft Matter Nanotechnol_184.pdf (Any fulltext), 683KB
 
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 Creators:
Platzman, Ilia1, 2, Author              
Kannenberg, Gerri1, 2, Author              
Janiesch, Jan-Willi1, 2, Author              
Matic, Jovana1, 2, Author              
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: antigen presentation; antigen-presenting cells; hydrogels; immunological synapse; nanopatterned interfaces; PEG-based biointerfaces; synthetic biology; T cells
 Abstract: T-cell interactions with antigen-presenting cells (APCs) are involved in nearly every immunological response in vivo, and consequently activate multiple signaling pathways that, in concert, initiate, drive, and regulate the body's adaptive and innate immune system responses to foreign pathogens and mutations. Although the fundamental characterization of T cell–APC interactions is a compelling goal, little progress has yet been made, mainly due to its extensive complexity. Therefore, engineering APC surrogates for the controlled manipulation of T cells in vitro has become an important strategy, particularly in medical applications, and can contribute to the understanding of the mechanisms underlying the ability of T cells to perform “intelligent” missions, such as acquiring, processing, and responding to environmental information. This chapter describes recently developed soft/elastic nanopatterned biomimetic systems for immunological applications. Particular attention is devoted to nanopatterned 2D and 3D artificial APC systems based on poly(ethylene glycol) (PEG) materials. These PEG-based APC surrogates allow independent control over material elasticity and the nanoscale distribution of bio-ligands and as a consequence are able to simulate ex vivo signals originating from naturally occurring APCs.

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Language(s): eng - English
 Dates: 2015-04-242015-06-15
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/9783527682157.ch07
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Title: Soft Matter Nanotechnology: From Structure to Function
Source Genre: Book
 Creator(s):
Chen, Xiadong1, Editor
Fuchs, Harald2, Editor
Affiliations:
1 Nanyang Technological University, N4.1-02-32, 50 Nanyang Avenue, Singapore 639798 , ou_persistent22            
2 Physikalisches Institut Universität Münster Wilhelm Klemm-Str. 10 D-48149 Münster Germany , ou_persistent22            
Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 187 - 215 Identifier: ISBN: 978-3-527-33722-4