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  Soft/Elastic Nanopatterned Biointerfaces in the Service of Cell Biology

Platzman, I., Gadomska, K. M., Janiesch, J.-W., Louban, I., Cavalcanti-Adam, E. A., & Spatz, J. P. (2014). Soft/Elastic Nanopatterned Biointerfaces in the Service of Cell Biology. In M. Piel, & M. Théry (Eds.), Micropatterning in Cell Biology, Part A (pp. 237-260). Amsterdam: Academic Press. doi:10.1016/B978-0-12-416742-1.00012-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0017-AE35-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-7DD6-8
Genre: Book Chapter

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MethCellBiol_119_2014_237.pdf (Any fulltext), 4MB
 
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 Creators:
Platzman, Ilia1, 2, Author              
Gadomska, Katharina M.1, 2, Author              
Janiesch, Jan-Willi1, 2, Author              
Louban, Ilia1, Author              
Cavalcanti-Adam, Elisabetta Ada1, 2, Author              
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: Biofunctionalization; Biointerfaces; Cell adhesion; Emulsion-based nanopatterning; Extracellular matrix; Hydrogels; Mechanosensing; Nanopatterned surfaces; PEG-DA; Substrate elasticity
 Abstract: Engineering of biomimetic interfaces has become a valuable tool for guiding cellular processes such as adhesion, spreading, motility, as well as proliferation, differentiation, and apoptosis. The interaction of cells with the extracellular matrix (ECM) or with other cells is involved in nearly every cellular response in vivo. Recent wide-ranging evidence shows that crosstalk between different environmental stimuli can have a tremendous impact on various cell functions. Therefore, the defined control of these stimuli in vitro can contribute to the understanding of the mechanisms underlying the ability of cells to perform "intelligent" missions like acquiring, processing, and responding to environmental information. This chapter summarizes recently developed nanopatterned biomimetic systems that allow independent control of different stimuli and illustrates their applications in cellular studies. Particular attention is devoted to nanopatterned 2D and 3D artificial ECM systems based on poly(ethylene glycol) materials. These allow independent control over the material elasticity and the nanoscale distribution of bioligands on the surface. In the case of engineering artificial cellular interfaces, additional attention has to be devoted to the critical functions of protein transport regulators, namely the cell membrane and the dynamic actin cytoskeleton; both are essential for the signaling activity of individual proteins and the entire cell.

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Language(s): eng - English
 Dates: 2014-01-162014
 Publication Status: Published in print
 Pages: 24
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Source 1

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Title: Micropatterning in Cell Biology, Part A
Source Genre: Book
 Creator(s):
Piel, Matthieu1, Editor
Théry, Manuel2, Editor
Affiliations:
1 Institut Curie, 75005 Paris, ou_persistent22            
2 LPCV / iRTSV / DSV / CEA, 38054 Grenoble, ou_persistent22            
Publ. Info: Amsterdam : Academic Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 237 - 260 Identifier: ISBN: 978-0-12-416742-1

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Title: Methods in Cell Biology
Source Genre: Series
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Pages: - Volume / Issue: 119 Sequence Number: - Start / End Page: - Identifier: -