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  Biophysical regulation of hematopoietic stem cells

Lee-Thedieck, C., & Spatz, J. P. (2014). Biophysical regulation of hematopoietic stem cells. Biomaterials Science, 2, 1548-1561. doi: 10.1039/C4BM00128A.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-30DB-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-5DA3-0
Genre: Journal Article

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 Creators:
Lee-Thedieck, Cornelia1, Author              
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: Blood is renewed throughout the entire life. The stem cells of the blood, called hematopoietic stem cells (HSCs), are responsible for maintaining a supply of all types of fresh blood cells. In contrast to other stem cells, the clinical application of these cells is well established and HSC transplantation is an established life-saving therapy for patients suffering from haematological disorders. Despite their efficient functionality throughout life in vivo, controlling HSC behaviour in vitro (including their proliferation and differentiation) is still a major task that has not been resolved with standard cell culture systems. Targeted HSC multiplication in vitro could be beneficial for many patients, because HSC supply is limited. The biology of these cells and their natural microenvironment – their niche – remain a matter of ongoing research. In recent years, evidence has come to light that HSCs are susceptible to physical stimuli. This makes the regulation of HSCs by engineering physical parameters a promising approach for the targeted manipulation of these cells for clinical applications. Nevertheless, the biophysical regulation of these cells is still poorly understood. This review sheds light on the role of biophysical parameters in HSC biology and outlines which knowledge on biophysical regulation identified in other cell types could be applied to HSCs.

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Language(s): eng - English
 Dates: 2014-04-162014-07-072014-07-172014
 Publication Status: Published in print
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1039/C4BM00128A
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Title: Biomaterials Science
Source Genre: Journal
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Publ. Info: Cambridge : Royal Society of Chemistry
Pages: - Volume / Issue: 2 Sequence Number: - Start / End Page: 1548 - 1561 Identifier: ISSN: 2047-4830
CoNE: /journals/resource/2047-4830