English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Engineering of synthetic cellular microenvironments: implications for immunity

Adutler-Lieber, S., Zaretsky, I., Platzman, I., Deeg, J., Friedman, N., Spatz, J. P., et al. (2014). Engineering of synthetic cellular microenvironments: implications for immunity. Journal of Autoimmunity, 54, 100-111. doi:10.1016/j.jaut.2014.05.003.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-30D0-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-7DC2-3
Genre: Journal Article

Files

show Files
hide Files
:
JAutoimmunity_54_2014_100.pdf (Any fulltext), 4MB
 
File Permalink:
-
Name:
JAutoimmunity_54_2014_100.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Adutler-Lieber, Shimrit, Author
Zaretsky, Irina, Author
Platzman, Ilia1, 2, Author              
Deeg, Janosch1, 2, Author              
Friedman, Nir, Author
Spatz, Joachim P.1, 2, Author              
Geiger, Benjamin, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

Content

show
hide
Free keywords: Adhesion signaling; Antigen presentation; Cell adhesion; Immune niche; Mechanobiology; Synthetic biology
 Abstract: In this article, we discuss novel synthetic approaches for studying the interactions of cells with their microenvironment. Notably, critical cellular processes such as growth, differentiation, migration, and fate determination, are tightly regulated by interactions with neighboring cells, and the surrounding extracellular matrix. Given the huge complexity of natural cellular environments, and their rich molecular and physical diversity, the mission of understanding "environmental signaling" at a molecular-mechanistic level appears to be extremely challenging. To meet these challenges, attempts have been made in recent years to design synthetic matrices with defined chemical and physical properties, which, artificial though they may be, could reveal basic "design principles" underlying the physiological processes. Here, we summarize recent developments in the characterization of the chemical and physical properties of cell sensing and adhesion, as well as the design and use of engineered, micro- to nanoscale patterned and confined environments, for systematic, comprehensive modulation of the cells' environment. The power of these biomimetic surfaces to highlight environmental signaling events in cells, and in immune cells in particular, will be discussed.

Details

show
hide
Language(s): eng - English
 Dates: 2014-05-182014-05-192014-06-182014-11-01
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Autoimmunity
  Other : J. Autoimmun.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Academic Press
Pages: - Volume / Issue: 54 Sequence Number: - Start / End Page: 100 - 111 Identifier: ISSN: 0896-8411
CoNE: https://pure.mpg.de/cone/journals/resource/954922649139