English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Model systems for studying cell adhesion and biomimetic actin networks

Brüggemann, D., Frohnmayer, J., & Spatz, J. P. (2014). Model systems for studying cell adhesion and biomimetic actin networks. Beilstein Journal of Nanotechnology, 5, 1193-1202. doi:10.3762/bjnano.5.131.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0023-C9C8-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-77E2-9
Genre: Journal Article

Files

show Files
hide Files
:
BeilsteinJNanotechnol_5_2014_1193.pdf (Any fulltext), 5MB
 
File Permalink:
-
Name:
BeilsteinJNanotechnol_5_2014_1193.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Locator:
https://dx.doi.org/10.3762/bjnano.5.131 (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Brüggemann, Dorothea1, Author              
Frohnmayer, Johannes1, 2, Author              
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

Content

show
hide
Free keywords: actin network; cell adhesion; giant unilamellar vesicle; integrin; lipid bilayer; synthetic cell; protein reconstitution; talin
 Abstract: Many cellular processes, such as migration, proliferation, wound healing and tumor progression are based on cell adhesion. Amongst different cell adhesion molecules, the integrin receptors play a very significant role. Over the past decades the function and signalling of various such integrins have been studied by incorporating the proteins into lipid membranes. These proteolipid structures lay the foundation for the development of artificial cells, which are able to adhere to substrates. To build biomimetic models for studying cell shape and spreading, actin networks can be incorporated into lipid vesicles, too. We here review the mechanisms of integrin-mediated cell adhesion and recent advances in the field of minimal cells towards synthetic adhesion. We focus on reconstituting integrins into lipid structures for mimicking cell adhesion and on the incorporation of actin networks and talin into model cells.

Details

show
hide
Language(s): eng - English
 Dates: 2014-01-302014-06-252014-08-012014
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Beilstein Journal of Nanotechnology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Frankfurt am Main : Beilstein-Institut
Pages: - Volume / Issue: 5 Sequence Number: - Start / End Page: 1193 - 1202 Identifier: ISSN: 2190-4286
CoNE: https://pure.mpg.de/cone/journals/resource/2190-4286