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  Perspective: flicking with flow: can microfluidics revolutionize the cancer research?

Chakraborty, S., & Das, T. (2013). Perspective: flicking with flow: can microfluidics revolutionize the cancer research? Biomicrofluidics, 7(1): 011811, pp. 1-20. doi:10.1063/1.4789750.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0018-7200-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-5EF7-E
Genre: Journal Article

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 Creators:
Chakraborty, Suman, Author
Das, Tamal1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: According to the World Health Organization, cancer is one of the leading causes of death worldwide. Cancer research, in its all facets, is truly interdisciplinary in nature, cutting across the fields of fundamental and applied sciences, as well as biomedical engineering. In recent years, microfluidics has been applied successfully in cancer research. There remain, however, many elusive features of this disease, where microfluidic systems could throw new lights. In addition, some inherent features of microfluidic systems remain unexploited in cancer research. In this article, we first briefly review the advancement of microfluidics in cancer biology. We then describe the biophysical aspects of cancer and outline how microfluidic system could be useful in developing a deeper understanding on the underlying mechanisms. We next illustrate the effects of the confined environment of microchannel on cellular dynamics and argue that the tissue microconfinement could be a crucial facet in tumor development. Lastly, we attempt to highlight some of the most important problems in cancer biology, to inspire next level of microfluidic applications in cancer research.

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Language(s): eng - English
 Dates: 2012-11-082012-12-202013-01-312013-01-01
 Publication Status: Published in print
 Pages: 20
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 Table of Contents: -
 Rev. Type: Peer
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Title: Biomicrofluidics
Source Genre: Journal
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Publ. Info: Melville, NY : American Institute of Physics
Pages: 20 Volume / Issue: 7 (1) Sequence Number: 011811 Start / End Page: 1 - 20 Identifier: ISSN: 1932-1058