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  Artificial Antigen-Presenting Interfaces in the Service of Immunology

Platzman, I., Janiesch, J.-W., Matic, J., & Spatz, J. P. (2013). Artificial Antigen-Presenting Interfaces in the Service of Immunology. Israel Journal of Chemistry, 53(9-10), 655-669. doi:10.1002/ijch.201300060.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0017-AC91-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-7DDA-F
Genre: Journal Article

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IsraelJChem_53_2013_655.pdf (Any fulltext), 3MB
 
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 Creators:
Platzman, Ilia1, 2, Author              
Janiesch, Jan-Willi1, 2, Author              
Matic, Jovana1, 2, Author              
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: antigens; cell recognition; immunology; nanostructures; T cells
 Abstract: While the beneficial impact of modifying and/or targeting T lymphocytes is becoming increasingly accepted in the treatment of different diseases, the road towards cell-based immunotherapy is still long and winding. Major challenges that remain include, amongst others, the guidance and exquisite regulation of immune processes ex vivo. In part, this is due to the difficulties of simulating ex vivo the intimate cellular interactions that occur between T cells and antigen-presenting cells (APCs). The fate of T cells is not solely regulated by the presence of certain molecules on the surface of APCs but also by their density and spatial distribution on the micro- and nanometric scale. Moreover, mechanical properties of APCs and force-dependent conformational changes during the formation of an immunological synapse (IS; a highly organized supramolecular complex at the T cell[BOND]APC interface), play a crucial role in T cell fate regulation. Various different technical means have been developed to create APC substitutes that are able to simulate ex vivo signals originating from naturally occurring APCs. Here, we review the performance of APC surrogates and discuss their contribution to understanding mechanisms underlying the ability of T cells to perform the “intelligent” mission of acquiring, processing and responding to environmental information.

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Language(s): eng - English
 Dates: 2013-06-072013-07-202013-09-162013-10-01
 Publication Status: Published in print
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/ijch.201300060
 Degree: -

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Title: Israel Journal of Chemistry
  Other : Isr. J. Chem.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag GmbH & Co. KGaA
Pages: - Volume / Issue: 53 (9-10) Sequence Number: - Start / End Page: 655 - 669 Identifier: ISSN: 0021-2148
CoNE: /journals/resource/954925408770