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  T cell activation is determined by the number of presented antigens

Deeg, J., Axmann, M., Matic, J., Liapis, A., Depoil, D., Afrose, J., et al. (2013). T cell activation is determined by the number of presented antigens. Nano Letters, 13(11), 5090-5097. doi:10.1021/nl403266t.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-1025-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-77DC-C
Genre: Journal Article

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NanoLett_13_2013_5619.pdf (Any fulltext), 5MB
 
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 Creators:
Deeg, Janosch1, 2, Author              
Axmann, Markus, Author
Matic, Jovana, Author
Liapis, Anastasia, Author
Depoil, David, Author
Afrose , Jehan, Author
Curado, Silvia, Author
Dustin, Michael L., Author
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: artificial antigen-presenting cell; immunological synapse; Nanopattern; nanostructures; T cell activation; TCR microclusters
 Abstract: Antigen recognition is a key event during T cell activation. Here, we introduce nanopatterned antigen arrays that mimic the antigen presenting cell surface during T cell activation. The assessment of activation related events revealed the requirement of a minimal density of 90-140 stimulating major histocompatibility complex class II proteins (pMHC) molecules per μm(2). We demonstrate that these substrates induce T cell responses in a pMHC dose-dependent manner and that the number of presented pMHCs dominates over local pMHC density.

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Language(s): eng - English
 Dates: 2013-10-052013-09-012013-10-112013
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Nano Letters
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 13 (11) Sequence Number: - Start / End Page: 5090 - 5097 Identifier: ISSN: 1530-6984
CoNE: /journals/resource/110978984570403