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  Marker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy images

Klein, K., Maier, T., Hirschfeld-Warneken, V. C., & Spatz, J. P. (2013). Marker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy images. Nano Letters, 13(11), 5474-5479. doi:10.1021/nl4030402.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0015-100B-7 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-77D7-5
Genre: Journal Article

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 Creators:
Klein, Katharina1, 2, Author           
Maier, Timo1, 2, Author           
Hirschfeld-Warneken, Vera Catherine, Author
Spatz, Joachim P.1, 2, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: Marker-free, phenotyping, tumor cells, cell adhesion, fractal analysis, RICM
 Abstract: Phenotyping of tumor cells by marker-free quantification is important for cancer diagnostics. For the first time, fractal analysis of reflection interference contrast microscopy images of single living cells was employed as a new method to distinguish between different nanoscopic membrane features of tumor cells. Since tumor progression correlates with a higher degree of chaos within the cell, it can be quantified mathematically by fractality. Our results show a high accuracy in identifying malignant cells with a failure chance of 3%, which is far better than today's applied methods.

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Language(s): eng - English
 Dates: 2013-09-262013-08-142013-09-302013-09-302013
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/nl4030402
URI: https://www.ncbi.nlm.nih.gov/pubmed/24079895
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Title: Nano Letters
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 13 (11) Sequence Number: - Start / End Page: 5474 - 5479 Identifier: ISSN: 1530-6984
CoNE: https://pure.mpg.de/cone/journals/resource/110978984570403