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  Toward controlling the formation, degradation behavior, and properties of hydrogels synthesized by aza-Michael reactions

Southan, A., Mateescu, M., Hagel, V., Bach, M., Schuh, C., Kleinhans, C., et al. (2013). Toward controlling the formation, degradation behavior, and properties of hydrogels synthesized by aza-Michael reactions. Macromolecular Chemistry and Physics, 214(16), 1865-1873. doi:10.1002/macp.201300359.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0015-1004-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-77CA-3
Genre: Journal Article

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MacromolChemPhys_214_2013_1865.pdf (Any fulltext), 3MB
 
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 Creators:
Southan, Alexander, Author
Mateescu, Markus, Author
Hagel, Valentin, Author
Bach, Monika, Author
Schuh, Christian, Author
Kleinhans, Claudia, Author
Kluger, Petra J., Author
Tussetschläger, Stefan, Author
Nuss, Isabell, Author
Haraszti, Tamas1, 2, Author              
Wegner, Seraphine V.1, 2, Author              
Spatz, Joachim P.1, 2, Author              
Böhm, Heike1, 2, Author              
Laschat, Sabine, Author
Tovar, Günter E.M., Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: aza-Michael reaction; hydrogels; hydrolytic stability; mechanical properties; pyridinium-based crosslinkers
 Abstract: The aza-Michael reaction of amino-functionalized polymers with acrylate and acrylamide crosslinkers for the formation of hydrogels is investigated. It is studied how far the reaction conditions (pH value, chemical structures of the compounds involved) influence the crosslinking and degradation rate of the gels. When crosslinking the polymer poly(1-glycidylpiperazine), high pH values lead to fast crosslinking. Fast degradation of β-aminoester crosslinks is observed when acrylate crosslinkers are used due to a neighboring group effect. With acrylamide crosslinkers, hydrolytically stable gels are formed, in which the shear moduli and swelling ratio can be adjusted and in which the extracts show no toxic effect on primary human fibroblasts, making them a promising material for biotechnological applications.

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Language(s): eng - English
 Dates: 2013-05-172013-07-112013-07-112013-08-26
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/macp.201300359
 Degree: -

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Title: Macromolecular Chemistry and Physics
Source Genre: Journal
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Publ. Info: Basel : Hüthig & Wepf
Pages: - Volume / Issue: 214 (16) Sequence Number: - Start / End Page: 1865 - 1873 Identifier: ISSN: 1022-1352
CoNE: https://pure.mpg.de/cone/journals/resource/954928497454