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  Desmosine-inspired cross-linkers for hyaluronan hydrogels

Hagel, V., Mateescu, M., Southan, A., Wegner, S. V., Nuss, I., Haraszti, T., et al. (2013). Desmosine-inspired cross-linkers for hyaluronan hydrogels. Scientific Reports, 3: 2043, pp. 1-5. doi:10.1038/srep02043.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-C69E-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-77B4-4
Genre: Journal Article

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 Creators:
Hagel, Valentin, Author
Mateescu, Markus, Author
Southan, Alexander, Author
Wegner, Seraphine V.1, 2, Author              
Nuss, Isabell, Author
Haraszti, Tamas1, 2, Author              
Kleinhans, Claudia, Author
Schuh, Christian, Author
Spatz, Joachim P.1, 2, Author              
Kluger, Petra J., Author
Bach, Monika, Author
Tussetschläger, Stefan, Author
Tovar, Günter E.M., Author
Laschat, Sabine, Author
Böhm, Heike1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: We designed bioinspired cross-linkers based on desmosine, the cross-linker in natural elastin, to prepare hydrogels with thiolated hyaluronic acid. These short, rigid cross-linkers are based on pyridinium salts (as in desmosine) and can connect two polymer backbones. Generally, the obtained semi-synthetic hydrogels are form-stable, can withstand repeated stress, have a large linear-elastic range, and show strain stiffening behavior typical for biopolymer networks. In addition, it is possible to introduce a positive charge to the core of the cross-linker without affecting the gelation efficiency, or consequently the network connectivity. However, the mechanical properties strongly depend on the charge of the cross-linker. The properties of the presented hydrogels can thus be tuned in a range important for engineering of soft tissues by controlling the cross-linking density and the charge of the cross-linker.

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Language(s): deu - German
 Dates: 2013-03-152013-05-312013-06-20
 Publication Status: Published online
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/srep02043
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 3 Sequence Number: 2043 Start / End Page: 1 - 5 Identifier: Other: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322