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  Diffusion and interaction in PEG-DA hydrogels

Hagel, V., Haraszti, T., & Böhm, H. (2013). Diffusion and interaction in PEG-DA hydrogels. Biointerphases, 8(1): 36, pp. 1-9. doi:10.1186/1559-4106-8-36.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-C6DD-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-7CF6-8
Genre: Journal Article

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Biointerphases_8_2013_36.pdf (Any fulltext), 176KB
 
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 Creators:
Hagel, Valentin, Author              
Haraszti, Tamas1, 2, Author              
Böhm, Heike1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: Polyethylenglycol (PEG) hydrogels are widely used as tuneable substrates for biological and technical applications due to their good biocompatibility and their high hydrophilicity. Here we compare the mesh size and diffusion characteristics of PEG hydrogels by analyzing the diffusion of solutes with different, well-defined sizes over long and short time scales. Interestingly, one can tune the mesh size and the density of the gel simply by changing the inital concentrations of the PEG-diacrylate (PEG-DA) polymer, which also enhances the solute uptake in equilibrium through the interaction with the PEG chains. This increased uptake can be characterized by an enhancement factor determined by partition ratio analysis. It increases linearly with the polymer volume fraction, but is not caused by immobilization inside the hydrogel as evident from FRAP measurements, thus rendering these hydrogels ideal materials for i.e. drug delivery applications.

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Language(s): eng - English
 Dates: 2013-08-232013-11-072013-12-06
 Publication Status: Published online
 Pages: 9
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 Rev. Method: Peer
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Title: Biointerphases
Source Genre: Journal
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Publ. Info: New York, NY : American Vacuum Society
Pages: - Volume / Issue: 8 (1) Sequence Number: 36 Start / End Page: 1 - 9 Identifier: ISSN: 1559-4106
CoNE: /journals/resource/1000000000220640_1