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  The general growth logistics of cell populations

Kilian, H. G., Bartkowiak, D., Kaufmann, D., & Kemkemer, R. (2008). The general growth logistics of cell populations. Cell Biochemistry and Biophysics, 51(2-3), 51-66. doi:10.1007/s12013-008-9012-9.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-40E1-D Versions-Permalink: http://hdl.handle.net/21.11116/0000-0000-DFCC-0
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CellBiochemBiophys_51_2008_51.pdf (beliebiger Volltext), 2MB
 
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 Urheber:
Kilian, H. G., Autor
Bartkowiak, D., Autor
Kaufmann, D., Autor              
Kemkemer, R.1, Autor              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

Inhalt

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Schlagwörter: Cell multiplication; Colonies; Populations; Structure and dynamics; Relaxation; Growth logistics
 Zusammenfassung: An increment model based on thermodynamics lays bare that the cell size distributions of archaea, prokaryotes and eukaryotes are optimized and belong to the same universal class. Yet, when a cell absorbs mass or signals are processed, these conditions are disturbed. Relaxation re-installs ideal growth conditions via an exponential process with a rate that slows down with the cell size. In a growing ensemble, a distribution of relaxation modes comes in existence, exactly defined by the universal cell size distribution. The discovery of nano-mechanic acoustic activities in cells led us to assume that in a growing ensemble acoustic signals may contribute significantly to the transmission of essential information about growth-induced disturbances to all cells, initiating that way coordinated relaxation. The frequency increases with the cell number shortening the period between successive signals. The completion of rearrangements occurring at a constant rate is thus progressively impaired, until cellular growth stops, totally. Due to this phenomenon, the so-called "relaxation-frequency-dispersion" cell colonies should exhibit a maximum cell number. In populations with large cell numbers, subsystems, behaving similar-like colonies, should form network-like patterns. Based on these ideas, we formulate equations that describe the growth curves of all cell types, verifying that way the general nature of the growth logistics.

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Sprache(n): eng - Englisch
 Datum: 2008-05-212008
 Publikationsstatus: Im Druck publiziert
 Seiten: 16
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
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Titel: Cell Biochemistry and Biophysics
  Andere : Cell Biochem Biophys
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Totowa, NJ : Humana Press
Seiten: - Band / Heft: 51 (2-3) Artikelnummer: - Start- / Endseite: 51 - 66 Identifikator: ISSN: 1085-9195
CoNE: /journals/resource/954927619054