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  Universal temporal response of fibroblasts adhering on cyclically stretched substrates

Jungbauer, S., Aragüés Rioja, B., Spatz, J. P., & Kemkemer, R. (2010). Universal temporal response of fibroblasts adhering on cyclically stretched substrates. In K. Garikipati, & E. M. Arruda (Eds.), IUTAM Symposium on Cellular, Molecular and Tissue Mechanics (pp. 103-109). Dordrecht [et al.]: Springer.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-3B23-D Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-79EF-0
Genre: Konferenzbeitrag

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Garikipati_2010_IUTAMSympCellMolTissueMechanics_103.pdf (beliebiger Volltext), 381KB
 
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Garikipati_2010_IUTAMSympCellMolTissueMechanics_103.pdf
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Eingeschränkt (Max Planck Institute for Medical Research, MHMF; )
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http://link.springer.com/content/pdf/10.1007%2F978-90-481-3348-2.pdf (beliebiger Volltext)
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https://dx.doi.org/10.1007/978-90-481-3348-2_9 (beliebiger Volltext)
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 Urheber:
Jungbauer, Simon1, 2, Autor           
Aragüés Rioja, Borja1, Autor           
Spatz, Joachim P.1, 2, Autor           
Kemkemer, Ralf1, Autor           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Zusammenfassung: It is well known that many cells adherent on a cyclically stretched substrate reorient nearly perpendicular to the applied stretching direction. Such periodic mechanical signals are characterized by the stretching amplitude and frequency ad many studies focus on the influence of the amplitude on the orientation behavior. However, little is know about the temporal characteristic and dynamics of this cellular response. Consequently, we developed an experimental stretch system for live cell imaging. Using this setup, we observed the dynamic reorientation of different human fibroblast types over a frequency range 0.01–10 s−1 and a constant stretching amplitude of 8%. We demonstrate an increasing mean cell orientation with an exponentially time characteristics. The characteristic time τ for the reorientation is frequency-dependent and is in a range from 1 to 5 h. This characteristic time is a function of frequency and follows a power law for frequencies below 1s−1,τ decreases with a power law as the frequency increases. For frequencies above 1s−1,τ is nearly constant and the kinetics of cell reorientation is in saturation. In addition, a threshold frequency is found below which no significant cell reorientation occurs. Our results are consistent for the two different human fibroblast types and indicate a saturation of molecular mechanisms of mechanotransduction or response machinery for subconfluent cells within the frequency regime under investigation.

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Sprache(n): eng - English
 Datum: 2010-01-01
 Publikationsstatus: Erschienen
 Seiten: 7
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 444500
DOI: 10.1007/978-90-481-3348-2_9
 Art des Abschluß: -

Veranstaltung

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Titel: IUTAM Symposium on Cellular, Molecular and Tissue Mechanics
Veranstaltungsort: Woods Hole, MA [USA]
Start-/Enddatum: 2008-06-18 - 2008-06-21

Entscheidung

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Projektinformation

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Quelle 1

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Titel: IUTAM Symposium on Cellular, Molecular and Tissue Mechanics
Genre der Quelle: Konferenzband
 Urheber:
Garikipati, K., Herausgeber
Arruda, E. M., Herausgeber
Affiliations:
-
Ort, Verlag, Ausgabe: Dordrecht [et al.] : Springer
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: 103 - 109 Identifikator: -

Quelle 2

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Titel: IUTAM Bookseries
Genre der Quelle: Reihe
 Urheber:
Gladwell, G. M. L., Herausgeber
Moreau, R., Herausgeber
Affiliations:
-
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 16 Artikelnummer: - Start- / Endseite: - Identifikator: -