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  Synthesis of nanostructured and biofunctionalized water-in-oil droplets as tools for homing T cells

Platzman, I., Janiesch, J.-W., & Spatz, J. P. (2013). Synthesis of nanostructured and biofunctionalized water-in-oil droplets as tools for homing T cells. Journal of the American Chemical Society, 135(9), 3339-3342. doi:10.1021/ja311588c.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-E3CC-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-5ED7-3
Genre: Journal Article

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http://pubs.acs.org/doi/pdf/10.1021/ja311588c (Any fulltext)
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 Creators:
Platzman, Ilia1, 2, Author           
Janiesch, Jan-Willi1, 2, Author           
Spatz, Joachim P.1, 2, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: Activation, ex vivo expansion of T cells, differentiation into a regulatory subset, and its phenotype-specific high-throughput selection represent major challenges in immunobiology. In part, this is due to the lack of technical means to synthesize suitable 3D extracellular systems to imitate ex vivo the cellular interactions between T cells and antigen-presenting cells (APCs). In this study, we synthesized a new type of gold-linked surfactant and used a drop-based microfluidic device to develop and characterize novel nanostructured and specifically biofunctionalized droplets of water-in-oil emulsions as 3D APC analogues. Combining flexible biofunctionalization with the pliable physical properties of the nanostructured droplets provided this system with superior properties in comparison with previously reported synthetic APC analogues.

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Language(s): eng - English
 Dates: 2012-12-012013-02-182013-02-252013-03-06
 Publication Status: Issued
 Pages: 4
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/ja311588c
URI: https://www.ncbi.nlm.nih.gov/pubmed/23419177
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806295/
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Title: Journal of the American Chemical Society
  Other : J. Am. Chem. Soc.
  Abbreviation : JACS
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 135 (9) Sequence Number: - Start / End Page: 3339 - 3342 Identifier: ISSN: 0002-7863
CoNE: https://pure.mpg.de/cone/journals/resource/954925376870