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  Intelligent induction of active biosystem responses at interfaces

Aydin, D., Hirschfeld-Warneken, V. C., Louban, I., & Spatz, J. P. (2011). Intelligent induction of active biosystem responses at interfaces. International Journal of Materials Research, 102(7), 796-808. doi:10.3139/146.110531.

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 Creators:
Aydin, Daniel1, Author              
Hirschfeld-Warneken, Vera C., Author
Louban, Ilia1, Author              
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: Block copolymernanolithography; Biofunktionalisation; Cell response; Self-assembled nanostructured surfaces; Biomolecule patterning
 Abstract: Intillegent interfaces make use of a fundamental molecular unterstanding of biosystems for the induction of their specific responses. Biological cells espacially have an enormous spatial resolution for oranizing their transmembrane receptor molecules, which is translated into specific cell functions. In turn, interfaces which provide a counter organization of molecules to required transmembrane receptor organizations are able to induce specific cell responses accordingly. This mission requires a patterning technology at interfaces which operates at the resolution of single molecules. Here, we report on self-assembly technologies for providing such patterns and their subsequent funktionalization with cell receptor binding molecules. Cells explore suchsurfaces and show a very distinct cell response. In the future, such interfaces may "learn" how to induce cell responses properly by analyzing cell responses and providing dynamically the adequate interface pattern which will allow cells to act more successfully in a given, unexpectedly complex environment.

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Language(s): eng - English
 Dates: 2011-02-022011-05-092011-07-01
 Publication Status: Published in print
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 570436
DOI: 10.3139/146.110531
 Degree: -

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Title: International Journal of Materials Research
  Abbreviation : Int. J. Mat. Res.
Source Genre: Journal
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Publ. Info: München, Germany : Hanser
Pages: - Volume / Issue: 102 (7) Sequence Number: - Start / End Page: 796 - 808 Identifier: ISSN: 1862-5282
CoNE: https://pure.mpg.de/cone/journals/resource/954925453910