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  Environmental constraints guide migration of malaria parasites during transmission

Hellmann, J. K., Münter, S., Kudryashev, M., Schulz, S., Heiss, K., Müller, A.-K., et al. (2011). Environmental constraints guide migration of malaria parasites during transmission. PLoS Pathogens, 7(6): e1002080. doi:10.1371/journal.ppat.1002080.

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 Creators:
Hellmann, Janina Kristin, Author
Münter, Sylvia, Author
Kudryashev, Mikhail, Author
Schulz, Simon1, Author              
Heiss, Kirsten, Author
Müller, Ann-Kristin, Author
Matuschewski, Kai, Author
Spatz, Joachim P.1, 2, Author              
Schwarz, Ulrich S., Author
Frischknecht, Friedrich, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: Migrating cells are guided in complex environments mainly by chemotaxis or structural cues presented by the surrounding tissue. During transmission of malaria, parasite motility in the skin is important for Plasmodium sporozoites to reach the blood circulation. Here we show that sporozoite migration varies in different skin environments the parasite encounters at the arbitrary sites of the mosquito bite. In order to systematically examine how sporozoite migration depends on the structure of the environment, we studied it in micro-fabricated obstacle arrays. The trajectories observed in vivo and in vitro closely resemble each other suggesting that structural constraints can be sufficient to guide Plasmodium sporozoites in complex environments. Sporozoite speed in different environments is optimized for migration and correlates with persistence length and dispersal. However, this correlation breaks down in mutant sporozoites that show adhesion impairment due to the lack of TRAP-like protein (TLP) on their surfaces. This may explain their delay in infecting the host. The flexibility of sporozoite adaption to different environments and a favorable speed for optimal dispersal ensures efficient host switching during malaria transmission.

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Language(s): eng - English
 Dates: 2010-11-172011-04-062011-06-16
 Publication Status: Published online
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: PLoS Pathogens
  Other : PLoS Pathog.
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 7 (6) Sequence Number: e1002080 Start / End Page: - Identifier: ISSN: 1553-7366
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000018830