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  Circular, nanostructured and biofunctionalized hydrogel microchannels for dynamic cell adhesion studies

Kruss, S., Erpenbeck, L., Schön, M. P., & Spatz, J. P. (2012). Circular, nanostructured and biofunctionalized hydrogel microchannels for dynamic cell adhesion studies. Lab on a Chip, 12(18), 3285-3289. doi:10.1039/C2LC40611J.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-4BCB-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-7C1E-0
Genre: Journal Article

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http://pubs.rsc.org/en/content/articlepdf/2012/lc/c2lc40611j (Any fulltext)
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https://dx.doi.org/10.1039/C2LC40611J (Any fulltext)
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 Creators:
Kruss, Sebastian1, 2, Author           
Erpenbeck, Luise, Author
Schön, Michael P., Author
Spatz, Joachim P.1, 2, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: We report on a method to fabricate biofunctionalized polyethylene glycol hydrogel microchannels with adjustable circular cross-sections. The inner channel surfaces are decorated with Aunanoparticle arrays of tunable density. These Au-nanoparticles are functionalized with biomolecules whereas the hydrogel material provides an inert and biocompatible background. This technology provides control over flow conditions, channel curvature and biomolecule density on the channel surface. It can be applied for biophysical studies of cell-surface interactions mimicking, for example, leukocyte interactions with the endothelial lining in small vessels.

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Language(s): eng - English
 Dates: 2012-05-282012-07-132012-08-022012-09-21
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 627545
DOI: 10.1039/C2LC40611J
URI: https://www.ncbi.nlm.nih.gov/pubmed/22858992
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448975/
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Title: Lab on a Chip
  Other : Lab Chip
Source Genre: Journal
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Publ. Info: Cambridge : Royal Society of Chemistry
Pages: - Volume / Issue: 12 (18) Sequence Number: - Start / End Page: 3285 - 3289 Identifier: Other: 1473-0197
CoNE: https://pure.mpg.de/cone/journals/resource/14730197