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  Artificial niches: biomimetic materials for hematopoietic stem cell culture

Lee-Thedieck, C., & Spatz, J. P. (2012). Artificial niches: biomimetic materials for hematopoietic stem cell culture. Macromolecular Rapid Communications, 33(17), 1432-1438. doi:10.1002/marc.201200219.

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MacromolRapidCommun_33_2012_1432.pdf (Any fulltext), 632KB
 
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 Creators:
Lee-Thedieck, Cornelia1, Author              
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: biomimetic; hematopoietic stem cell niche; hydrogels; microstructure; nanostructure
 Abstract: Hematopoietic stem cells (HSCs) are indispensable for the treatment of patients with hematological disorders such as leukemia. However, the amount of available transplantable HSCs is limited. Therefore, new approaches to multiply HSCs in the laboratory are needed. Promising biomimetic technologies for HSC expansion are currently developed. This feature article gives an insight into the significance of this approach and introduces the essential building blocks (cells, matrix, and scaffolds) of biomimetic materials. Some recent strategies are highlighted and the challenges and possible applications of such materials are discussed.

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Language(s): eng - English
 Dates: 2012-04-262012-03-282012-07-202012-09-14
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Macromolecular Rapid Communications
Source Genre: Journal
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Publ. Info: Weinheim, Germany : Wiley-VCH
Pages: - Volume / Issue: 33 (17) Sequence Number: - Start / End Page: 1432 - 1438 Identifier: ISSN: 1022-1336
CoNE: https://pure.mpg.de/cone/journals/resource/1022-1336