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  Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing

Arnold, M., Hirschfeld-Warneken, V. C., Lohmueller, T., Heil, P., Blümmel, J., Cavalcanti-Adam, E. A., et al. (2008). Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing. Nano Letters, 8(7), 2063-2069. doi:10.1021/nl801483w.

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 Creators:
Arnold, Marco1, Author              
Hirschfeld-Warneken, Vera C., Author
Lohmueller, Theobald1, Author              
Heil, Patrick, Author
Blümmel, Jacques, Author
Cavalcanti-Adam, Elisabetta A.1, 2, Author              
López-García, Mónica, Author
Walther, Paul, Author
Kessler, Horst, Author
Geiger, Benjamin, Author
Spatz, Joachim P.1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: Cell interactions with adhesive surfaces play a vital role in the regulation of cell proliferation, viability, and differentiation, and affect multiple biological processes. Since cell adhesion depends mainly on the nature and density of the adhesive ligand molecules, spatial molecular patterning, which enables the modulation of adhesion receptor clustering, might affect both the structural and the signaling activities of the adhesive interaction. We herein show that cells plated on surfaces that present a molecularly defined spacing gradient of an integrin RGD ligand can sense small but consistent differences in adhesive ligand spacing of about 1 nm across the cell diameter, which is approximately 61 mum when the spacing includes 70 nm. Consequently, these positional cues induce cell polarization and initiate cell migration and signaling. We propose that differential positional clustering of the integrin transmembrane receptors is used by cells for exploring and interpreting their environment, at high spatial sensitivity.

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Language(s): eng - English
 Dates: 2008-05-232008-06-182008-07-01
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Internal
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Title: Nano Letters
  Abbreviation : Nano Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 8 (7) Sequence Number: - Start / End Page: 2063 - 2069 Identifier: ISSN: 1530-6984
CoNE: https://pure.mpg.de/cone/journals/resource/110978984570403