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  A theoretical description of elastic pillar substrates in biophysical experiments

Mohrdieck, C., Wanner, A., Roos, W., Roth, A., Sackmann, E., Spatz, J. P., et al. (2005). A theoretical description of elastic pillar substrates in biophysical experiments. ChemPhysChem, 6(8), 1492-1498. doi:10.1002/cphc.200500109.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-266A-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-9BC1-3
Genre: Journal Article

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ChemPhysChem_6_2005_1492.pdf (Any fulltext), 176KB
 
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 Creators:
Mohrdieck, Camilla, Author
Wanner, Alexander, Author
Roos, Wouter1, Author              
Roth, Alexander, Author
Sackmann, Erich, Author
Spatz, Joachim P.1, 2, Author              
Arzt, Eduard, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: biophysics; fiber networks; self-assembly; sensors; traction forces
 Abstract: Arrays of elastic pillars are used in biophysical experiments as sensors for traction forces. The evaluation of the forces can be complicated if they are coupled to the pillar displacements over large distances. This is the case if many of the pillars are interconnected by elastic linkages as, for example, in fiber networks that are grown on top of pillars. To calculate the traction forces in such a network, we developed a set of nonlinear inhomogeneous equations relating the forces in the linking elements to the resulting pillar deflections. We chose a homogeneous, activated two-dimensional network of cytoskeletal actin filaments to illustrate that a pillar substrate is generally not a force sensor but a force-gradient sensor. In homogeneous networks the forces acting along the filaments can be approximated by analyzing only pillar deflections in the edge zones of the substrate and by integration over the corresponding force gradients.

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Language(s): eng - English
 Dates: 2005-05-202005-02-222005-08-052005-08-12
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: ChemPhysChem
Source Genre: Journal
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Publ. Info: Weinheim, Germany : Wiley-VCH
Pages: - Volume / Issue: 6 (8) Sequence Number: - Start / End Page: 1492 - 1498 Identifier: ISSN: 1439-4235
CoNE: https://pure.mpg.de/cone/journals/resource/954925409790