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  Disaggregases in 4 dimensions

Barends, T., Werbeck, N. D., & Reinstein, J. (2010). Disaggregases in 4 dimensions. Current Opinion in Structural Biology, 20(1), 46-53. doi:10.1016/j.sbi.2009.12.014.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-1FBD-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-1FBE-3
Genre: Journal Article
Alternative Title : Disaggregases in 4 dimensions

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CurrOpinStructBiol_20_2010_46.pdf (Any fulltext), 562KB
 
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 Creators:
Barends, Thomas1, Author              
Werbeck, Nicolas D.1, Author              
Reinstein, Jochen1, Author              
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1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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 Abstract: Non-destructive dissagregation of protein aggregates is a formidable task mediated by the specialized AAA+ chaperone Hsp104/ClpB in combination with the Hsp70/DnaK chaperone system. The exact mechanism of how the hexameric Hsp104/ClpB proteins perform the task of protein disaggregation or remodeling is largely unknown. The process is ATP-dependent and tight coupling between the ATPase domains within the hexameric ring-complex could be observed. While substrate translocation through the central pore of the ring-shaped hexamer appears to be a central mechanism shared with other AAA+ proteins, a middle domain unique to Hsp104/ClpB could be involved in specific features of the Hsp/ClpB mechanism and its regulation. Recent findings underline the dynamic properties of the molecular complex and might provide a basis to understand substrate interaction, regulation of disaggregation activity, and interactions with co-chaperones.

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Language(s): eng - English
 Dates: 2010-01-182010-02-01
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664620
DOI: 10.1016/j.sbi.2009.12.014
URI: http://www.ncbi.nlm.nih.gov/pubmed/20083401
Other: 7565
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Title: Current Opinion in Structural Biology
  Other : Curr. Opin. Struct. Biol.
Source Genre: Journal
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Publ. Info: London : Elsevier Current Trends
Pages: - Volume / Issue: 20 (1) Sequence Number: - Start / End Page: 46 - 53 Identifier: ISSN: 0959-440X
CoNE: https://pure.mpg.de/cone/journals/resource/954925578067