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  Reducing future fears by suppressing the brain mechanisms underlying episodic simulation

Benoit, R. G., Davies, D. J., & Anderson, M. C. (2016). Reducing future fears by suppressing the brain mechanisms underlying episodic simulation. Proceedings of the National Academy of Sciences of the United States of America, 113(52), E8492-E8501. doi:10.1073/pnas.1606604114.

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資料種別: 学術論文

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 作成者:
Benoit, Roland G.1, 著者           
Davies, Daniel J.2, 著者
Anderson, Michael C.3, 4, 著者
所属:
1Max Planck Research Group Adaptive Memory, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2295691              
2Department of Psychiatry, University of Cambridge, United Kingdom, ou_persistent22              
3MRC Cognition and Brain Sciences Unit, University of Cambridge, United Kingdom, ou_persistent22              
4Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom, ou_persistent22              

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キーワード: Suppression; Episodic simulation; Anxiety Cognitive control; Prefrontal cortex
 要旨: Imagining future events conveys adaptive benefits, yet recurrent simulations of feared situations may help to maintain anxiety. In two studies, we tested the hypothesis that people can attenuate future fears by suppressing anticipatory simulations of dreaded events. Participants repeatedly imagined upsetting episodes that they feared might happen to them and suppressed imaginings of other such events. Suppressing imagination engaged the right dorsolateral prefrontal cortex, which modulated activation in the hippocampus and in the ventromedial prefrontal cortex (vmPFC). Consistent with the role of the vmPFC in providing access to details that are typical for an event, stronger inhibition of this region was associated with greater forgetting of such details. Suppression further hindered participants’ ability to later freely envision suppressed episodes. Critically, it also reduced feelings of apprehensiveness about the feared scenario, and individuals who were particularly successful at down-regulating fears were also less trait-anxious. Attenuating apprehensiveness by suppressing simulations of feared events may thus be an effective coping strategy, suggesting that a deficiency in this mechanism could contribute to the development of anxiety.

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言語: eng - English
 日付: 2016-05-132016-11-112016-12-132016-12-27
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): DOI: 10.1073/pnas.1606604114
PMID: 27965391
PMC: PMC5206570
その他: Epub 2016
 学位: -

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Project name : -
Grant ID : MC-A060-5PR00; MC_U105597121
Funding program : -
Funding organization : Medical Research Council UK (MRC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Foundation CELLEX (MPG)

出版物 1

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出版物名: Proceedings of the National Academy of Sciences of the United States of America
  その他 : Proc. Acad. Sci. USA
  その他 : Proc. Acad. Sci. U.S.A.
  省略形 : PNAS
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Washington, D.C. : National Academy of Sciences
ページ: - 巻号: 113 (52) 通巻号: - 開始・終了ページ: E8492 - E8501 識別子(ISBN, ISSN, DOIなど): ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230