ausblenden:
Schlagwörter:
Psychopathology, psychosis, depression, environment, epidemiology
Zusammenfassung:
Background: We investigated to what degree environmental exposure
(childhood trauma, urbanicity, cannabis use, and discrimination) impacts
symptom connectivity using both continuous and categorical measures of
psychopathology.
Methods: Outcomes were continuous symptom dimensions of self-reported
psychopathology using the Self-report Symptom Checklist-90-R in 3021
participants from The Early Developmental Stages of the Psychopathology
(EDSP) study and binary DSM-III-R categories of mental disorders and a
binary measure of psychotic symptoms in 7076 participants from The
Netherlands Mental Health Survey and Incidence Study (NEMESIS-1). For
each symptom dimension in the EDSP and mental disorder in the NEMESIS-1
as the dependent variable, regression analyses were carried out
including each of the remaining symptom dimensions/mental disorders and
its interaction with cumulative environmental risk load (the sum score
of environmental exposures) as independent variables.
Results: All symptom dimensions in the EDSP and related diagnostic
categories in the NEMESIS-1 were strongly associated with each other,
and environmental exposures increased the degree of symptom connectivity
in the networks in both cohorts.
Conclusions: Our findings showing strong connectivity across symptom
dimensions and related binary diagnostic constructs in two independent
population cohorts provide further evidence for the conceptualization of
psychopathology as a contextually sensitive network of mutually
interacting symptoms.
