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  Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations

Fehringer, G., Kraft, P., Pharoah, P. D., Eeles, R. A., Chatterjee, N., Schumacher, F. R., et al. (2016). Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. CANCER RESEARCH, 76(17), 5103-5114. doi:10.1158/0008-5472.CAN-15-2980.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-5963-E Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-5964-C
Genre: Journal Article

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 Creators:
Fehringer, Gordon1, Author
Kraft, Peter1, Author
Pharoah, Paul D.1, Author
Eeles, Rosalind A.1, Author
Chatterjee, Nilanjan1, Author
Schumacher, Fredrick R.1, Author
Schildkraut, Joellen M.1, Author
Lindstrom, Sara1, Author
Brennan, Paul1, Author
Bickeboller, Heike1, Author
Houlston, Richard S.1, Author
Landi, Maria Teresa1, Author
Caporaso, Neil1, Author
Risch, Angela1, Author
Al Olama, Ali Amin1, Author
Berndt, Sonja I.1, Author
Giovannucci, Edward L.1, Author
Gronberg, Henrik1, Author
Kote-Jarai, Zsofia1, Author
Ma, Jing1, Author
Muir, Kenneth1, AuthorStampfer, Meir J.1, AuthorStevens, Victoria L.1, AuthorWiklund, Fredrik1, AuthorWillett, Walter C.1, AuthorGoode, Ellen L.1, AuthorPermuth, Jennifer B.1, AuthorRisch, Harvey A.1, AuthorReid, Brett M.1, AuthorBezieau, Stephane1, AuthorBrenner, Hermann1, AuthorChan, Andrew T.1, AuthorChang-Claude, Jenny1, AuthorHudson, Thomas J.1, AuthorKocarnik, Jonathan K.1, AuthorNewcomb, Polly A.1, AuthorSchoen, Robert E.1, AuthorSlattery, Martha L.1, AuthorWhite, Emily1, AuthorAdank, Muriel A.1, AuthorAhsan, Habibul1, AuthorAittomaki, Kristiina1, AuthorBaglietto, Laura1, AuthorBlomquist, Carl1, AuthorCanzian, Federico1, AuthorCzene, Kamila1, Authordos-Santos-Silva, Isabel1, AuthorEliassen, A. Heather1, AuthorFigueroa, Jonine D.1, AuthorFlesch-Janys, Dieter1, AuthorFletcher, Olivia1, AuthorGarcia-Closas, Montserrat1, AuthorGaudet, Mia M.1, AuthorJohnson, Nichola1, AuthorHall, Per1, AuthorHazra, Aditi1, AuthorHein, Rebecca1, AuthorHofman, Albert1, AuthorHopper, John L.1, AuthorIrwanto, Astrid1, AuthorJohansson, Mattias1, AuthorKaaks, Rudolf1, AuthorKibriya, Muhammad G.1, AuthorLichtner, Peter1, AuthorLiu, Jianjun1, AuthorLund, Eiliv1, AuthorMakalic, Enes1, AuthorMeindl, Alfons1, AuthorMüller-Myhsok, Bertram2, Author           Muranen, Taru A.1, AuthorNevanlinna, Heli1, AuthorPeeters, Petra H.1, AuthorPeto, Julian1, AuthorPrentice, Ross L.1, AuthorRahman, Nazneen1, AuthorSanchez, Maria Jose1, AuthorSchmidt, Daniel F.1, AuthorSchmutzler, Rita K.1, AuthorSouthey, Melissa C.1, AuthorTamimi, Rulla1, AuthorTravis, Ruth C.1, AuthorTurnbull, Clare1, AuthorUitterlinden, Andre G.1, AuthorWang, Zhaoming1, AuthorWhittemore, Alice S.1, AuthorYang, Xiaohong R.1, AuthorZheng, Wei1, AuthorBuchanan, Daniel D.1, AuthorCasey, Graham1, AuthorConti, David V.1, AuthorEdlund, Christopher K.1, AuthorGallinger, Steven1, AuthorHaile, Robert W.1, AuthorJenkins, Mark1, AuthorLe Marchand, Loic1, AuthorLi, Li1, AuthorLindor, Noralene M.1, AuthorSchmit, Stephanie L.1, AuthorThibodeau, Stephen N.1, AuthorWoods, Michael O.1, AuthorRafnar, Thorunn1, AuthorGudmundsson, Julius1, AuthorStacey, Simon N.1, AuthorStefansson, Kari1, AuthorSulem, Patrick1, AuthorChen, Y. Ann1, AuthorTyrer, Jonathan P.1, AuthorChristiani, David C.1, AuthorWei, Yongyue1, AuthorShen, Hongbing1, AuthorHu, Zhibin1, AuthorShu, Xiao-Ou1, AuthorShiraishi, Kouya1, AuthorTakahashi, Atsushi1, AuthorBosse, Yohan1, AuthorObeidat, Ma'en1, AuthorNickle, David1, AuthorTimens, Wim1, AuthorFreedman, Matthew L.1, AuthorLi, Qiyuan1, AuthorSeminara, Daniela1, AuthorChanock, Stephen J.1, AuthorGong, Jian1, AuthorPeters, Ulrike1, AuthorGruber, Stephen B.1, AuthorAmos, Christopher I.1, AuthorSellers, Thomas A.1, AuthorEaston, Douglas F.1, AuthorHunter, David J.1, AuthorHaiman, Christopher A.1, AuthorHenderson, Brian E.1, AuthorHung, Rayjean J.1, Author more..
Affiliations:
1external, ou_persistent22              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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 Abstract: Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus atCDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. (C) 2016 AACR.

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Language(s): eng - English
 Dates: 2016-09-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000382298900020
DOI: 10.1158/0008-5472.CAN-15-2980
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Title: CANCER RESEARCH
Source Genre: Journal
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Pages: - Volume / Issue: 76 (17) Sequence Number: - Start / End Page: 5103 - 5114 Identifier: ISSN: 0008-5472