Knockdown of corticotropin-releasing factor 1 receptors in the ventral 
tegmental area enhances conditioned fear

Chen, Nicola A.; Ganella, Despina E.; Bathgate, Ross A. D.; Chen, Alon; Lawrence, Andrew J.; Kim, Jee Hyun

doi:10.1016/j.euroneuro.2016.06.002

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Knockdown of corticotropin-releasing factor 1 receptors in the ventral tegmental area enhances conditioned fear

Chen, N. A., Ganella, D. E., Bathgate, R. A. D., Chen, A., Lawrence, A. J., & Kim, J. H. (2016). Knockdown of corticotropin-releasing factor 1 receptors in the ventral tegmental area enhances conditioned fear. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 26(9), 1533-1540. doi:10.1016/j.euroneuro.2016.06.002.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-5793-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-5794-0

Genre: Journal Article

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Creators:
Chen, Nicola A.¹, Author
Ganella, Despina E.¹, Author
Bathgate, Ross A. D.¹, Author
Chen, Alon², Author
Lawrence, Andrew J.¹, Author
Kim, Jee Hyun¹, Author

Affiliations:
1external, ou_persistent22
2Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294

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Free keywords: Stress, fear, VTA, CRF, memory

Abstract: The neuropeptide corticotropin-releasing factor (CRF) coordinates the physiological and behavioural responses to stress. CRF receptors are highly expressed in the ventral tegmental area (VTA), an important region for motivated behaviour. Therefore, we examined the role of CRF receptor type 1 (CRFR1) in the VTA in conditioned fear, using a viral-mediated RNA interference approach. Following stereotaxic injection of a lentivirus that contained either shCRF-R1 or a control sequence, mice received tone-footshock pairings. Intra-VTA shCRF-R1 did not affect tone-elicited freezing during conditioning. Once conditioned fear was acquired, however, shCRF-R1 mice consistently showed stronger freezing to the tone even after extinction and reinstatement. These results implicate a novel role of VTA CRF-R1 in conditioned fear, and suggest how stress may modulate aversive learning and memory. (C) 2016 Elsevier B.V. and ECNP. All rights reserved.

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Language(s): eng - English

Dates: Date issued: 2016-09

Publication Status: Issued

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Identifiers: ISI: 000383009800019
DOI: 10.1016/j.euroneuro.2016.06.002

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Title: EUROPEAN NEUROPSYCHOPHARMACOLOGY

Source Genre: Journal

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Pages: - Volume / Issue: 26 (9) Sequence Number: - Start / End Page: 1533 - 1540 Identifier: ISSN: 0924-977X