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  Epigenetic Signatures of Cigarette Smoking

Joehanes, R., Just, A. C., Marioni, R. E., Pilling, L. C., Reynolds, L. M., Mandaviya, P. R., Guan, W., Xu, T., Elks, C. E., Aslibekyan, S., Moreno-Macias, H., Smith, J. A., Brody, J. A., Dhingra, R., Yousefi, P., Pankow, J. S., Kunze, S., Shah, S. H., McRae, A. F., Lohman, K., Sha, J., Absher, D. M., Ferrucci, L., Zhao, W., Demerath, E. W., Bressler, J., Grove, M. L., Huan, T., Liu, C., Mendelson, M. M., Yao, C., Kiel, D. P., Peters, A., Wang-Sattler, R., Visscher, P. M., Wray, N. R., Starr, J. M., Ding, J., Rodriguez, C. J., Wareham, N. J., Irvin, M. R., Zhi, D., Barrdahl, M., Vineis, P., Ambatipudi, S., Uitterlinden, A. G., Hofman, A., Schwartz, J., Colicino, E., Hou, L., Vokonas, P. S., Hernandez, D. G., Singleton, A. B., Bandinelli, S., Turner, S. T., Ware, E. B., Smith, A. K., Klengel, T., Binder, E. B., Psaty, B. M., Taylor, K. D., Gharib, S. A., Swenson, B. R., Liang, L., DeMeo, D. L., O'Connor, G. T., Herceg, Z., Ressler, K. J., Conneely, K. N., Sotoodehnia, N., Kardia, S. L. R., Melzer, D., Baccarelli, A. A., van Meurs, J. B. J., Romieu, I., Arnett, D. K., Ong, K. K., Liu, Y., Waldenberger, M., Deary, I. J., Fornage, M., Levy, D., & London, S. J. (2016). Epigenetic Signatures of Cigarette Smoking. CIRCULATION-CARDIOVASCULAR GENETICS, 9(5), 436-447. doi:10.1161/CIRCGENETICS.116.001506.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002C-4A16-2 版のパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002C-4A17-F
資料種別: 学術論文

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 作成者:
Joehanes, Roby1, 著者
Just, Allan C.1, 著者
Marioni, Riccardo E.1, 著者
Pilling, Luke C.1, 著者
Reynolds, Lindsay M.1, 著者
Mandaviya, Pooja R.1, 著者
Guan, Weihua1, 著者
Xu, Tao1, 著者
Elks, Cathy E.1, 著者
Aslibekyan, Stella1, 著者
Moreno-Macias, Hortensia1, 著者
Smith, Jennifer A.1, 著者
Brody, Jennifer A.1, 著者
Dhingra, Radhika1, 著者
Yousefi, Paul1, 著者
Pankow, James S.1, 著者
Kunze, Sonja1, 著者
Shah, Sonia H.1, 著者
McRae, Allan F.1, 著者
Lohman, Kurt1, 著者
Sha, Jin1, 著者Absher, Devin M.1, 著者Ferrucci, Luigi1, 著者Zhao, Wei1, 著者Demerath, Ellen W.1, 著者Bressler, Jan1, 著者Grove, Megan L.1, 著者Huan, Tianxiao1, 著者Liu, Chunyu1, 著者Mendelson, Michael M.1, 著者Yao, Chen1, 著者Kiel, Douglas P.1, 著者Peters, Annette1, 著者Wang-Sattler, Rui1, 著者Visscher, Peter M.1, 著者Wray, Naomi R.1, 著者Starr, John M.1, 著者Ding, Jingzhong1, 著者Rodriguez, Carlos J.1, 著者Wareham, Nicholas J.1, 著者Irvin, Marguerite R.1, 著者Zhi, Degui1, 著者Barrdahl, Myrto1, 著者Vineis, Paolo1, 著者Ambatipudi, Srikant1, 著者Uitterlinden, Andre G.1, 著者Hofman, Albert1, 著者Schwartz, Joel1, 著者Colicino, Elena1, 著者Hou, Lifang1, 著者Vokonas, Pantel S.1, 著者Hernandez, Dena G.1, 著者Singleton, Andrew B.1, 著者Bandinelli, Stefania1, 著者Turner, Stephen T.1, 著者Ware, Erin B.1, 著者Smith, Alicia K.1, 著者Klengel, Torsten2, 著者           Binder, Elisabeth B.2, 著者           Psaty, Bruce M.1, 著者Taylor, Kent D.1, 著者Gharib, Sina A.1, 著者Swenson, Brenton R.1, 著者Liang, Liming1, 著者DeMeo, Dawn L.1, 著者O'Connor, George T.1, 著者Herceg, Zdenko1, 著者Ressler, Kerry J.1, 著者Conneely, Karen N.1, 著者Sotoodehnia, Nona1, 著者Kardia, Sharon L. R.1, 著者Melzer, David1, 著者Baccarelli, Andrea A.1, 著者van Meurs, Joyce B. J.1, 著者Romieu, Isabelle1, 著者Arnett, Donna K.1, 著者Ong, Ken K.1, 著者Liu, Yongmei1, 著者Waldenberger, Melanie1, 著者Deary, Ian J.1, 著者Fornage, Myriam1, 著者Levy, Daniel1, 著者London, Stephanie J.1, 著者 全て表示
所属:
1external, ou_persistent22              
2Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              

内容説明

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キーワード: biomarkers, genome-wide association study, meta-analysis, methylation, smoking
 要旨: Background DNA methylation leaves a long-term signature of smoking exposure and is one potential mechanism by which tobacco exposure predisposes to adverse health outcomes, such as cancers, osteoporosis, lung, and cardiovascular disorders. Methods and Results To comprehensively determine the association between cigarette smoking and DNA methylation, we conducted a meta-analysis of genome-wide DNA methylation assessed using the Illumina BeadChip 450K array on 15907 blood-derived DNA samples from participants in 16 cohorts (including 2433 current, 6518 former, and 6956 never smokers). Comparing current versus never smokers, 2623 cytosine-phosphate-guanine sites (CpGs), annotated to 1405 genes, were statistically significantly differentially methylated at Bonferroni threshold of P<1x10(-7) (18760 CpGs at false discovery rate <0.05). Genes annotated to these CpGs were enriched for associations with several smoking-related traits in genome-wide studies including pulmonary function, cancers, inflammatory diseases, and heart disease. Comparing former versus never smokers, 185 of the CpGs that differed between current and never smokers were significant P<1x10(-7) (2623 CpGs at false discovery rate <0.05), indicating a pattern of persistent altered methylation, with attenuation, after smoking cessation. Transcriptomic integration identified effects on gene expression at many differentially methylated CpGs. Conclusions Cigarette smoking has a broad impact on genome-wide methylation that, at many loci, persists many years after smoking cessation. Many of the differentially methylated genes were novel genes with respect to biological effects of smoking and might represent therapeutic targets for prevention or treatment of tobacco-related diseases. Methylation at these sites could also serve as sensitive and stable biomarkers of lifetime exposure to tobacco smoke.

資料詳細

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言語: eng - English
 日付: 2016-10
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: ISI: 000386593700007
DOI: 10.1161/CIRCGENETICS.116.001506
 学位: -

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出版物 1

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出版物名: CIRCULATION-CARDIOVASCULAR GENETICS
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 9 (5) 通巻号: - 開始・終了ページ: 436 - 447 識別子（ISBN, ISSN, DOIなど）: ISSN: 1942-325X