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  Hippocampal GluA1 expression in Gria1−/− mice only partially restores spatial memory performance deficits

Freudenberg, F., Resnik, E., Kolleker, A., Celikel, T., Sprengel, R., & Seeburg, P. H. (2016). Hippocampal GluA1 expression in Gria1−/− mice only partially restores spatial memory performance deficits. Neurobiology of learning and memory, 135, 83-90. doi:10.1016/j.nlm.2016.07.005.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-366C-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-3B01-7
Genre: Journal Article
Alternative Title : Hippocampal GluA1 expression in Gria1-/- mice only partially restores spatial memory performance deficits

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NeurobiolLearnMem_135_2016_83.pdf (Any fulltext), 2MB
 
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 Creators:
Freudenberg, Florian1, Author              
Resnik, Evgeny1, Author              
Kolleker, Alexander1, Author              
Celikel, Tansu, Author
Sprengel, Rolf1, Author              
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: Mouse; GluR1; GluR-A; Viral gene transfer; Adeno-associated virus
 Abstract: Spatial working memory (SWM) is an essential cognitive function important for survival in a competitive environment. In rodents SWM requires an intact hippocampus and SWM expression is impaired in mice lacking the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA1 (Gria1−/− mice). Here we used viral gene transfer to show that re-expression of GluA1 in the hippocampus can affect the behavioral performance of GluA1 deficient mice. We found that Gria1−/− mice with hippocampus-specific rescue of GluA1 expression (Gria1Hpc mice) are more anxious, less hyperactive and only partly impaired in SWM expression in the Y-maze spatial novelty preference paradigm compared to Gria1−/− mice. However, Gria1Hpc mice still express SWM performance deficits when tested in the rewarded alternation T-maze task. Thus, the restoration of hippocampal function affects several behaviors of GluA1 deficient mice – including SWM expression – in different tasks. The virus-mediated GluA1 expression in Gria1−/− mice is not sufficient for a comprehensive SWM restoration, suggesting that both hippocampal as well as extra-hippocampal GluA1-containing AMPA receptors contribute to SWM.

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Language(s): eng - English
 Dates: 2016-07-042016-05-052016-07-072016-07-112016-11-01
 Publication Status: Published in print
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.nlm.2016.07.005
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Title: Neurobiology of learning and memory
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 135 Sequence Number: - Start / End Page: 83 - 90 Identifier: ISSN: 1074-7427