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  Body topography parcellates human sensory and motor cortex

Kuehn, E., Dinse, J., Jakobsen, E., Long, X., Schäfer, A., Bazin, P.-L., et al. (2017). Body topography parcellates human sensory and motor cortex. Cerebral Cortex, 27(7), 3790-3805. doi:10.1093/cercor/bhx026.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-36C6-A Version Permalink: http://hdl.handle.net/21.11116/0000-0005-0F41-2
Genre: Journal Article

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 Creators:
Kuehn, Esther1, 2, 3, 4, Author              
Dinse, Juliane5, 6, Author              
Jakobsen, Estrid7, Author              
Long, Xiangyu1, Author              
Schäfer, Andreas6, Author              
Bazin, Pierre-Louis1, 6, Author              
Villringer, Arno1, Author              
Sereno, Martin I.2, Author
Margulies, Daniel S.7, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Psychology and Language Sciences, University College London, United Kingdom, ou_persistent22              
3Center for Behavioral Brain Sciences, Magdeburg, Germany, ou_persistent22              
4Aging and Cognition Research Group, German Center for Neurodegenerative Diseases, Magdeburg, Germany, ou_persistent22              
5Faculty of Computer Science, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
6Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
7Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              

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Free keywords: Embodiment; Hand–face border; Parcellation; Plasticity; Septa
 Abstract: The cytoarchitectonic map as proposed by Brodmann currently dominates models of human sensorimotor cortical structure, function, and plasticity. According to this model, primary motor cortex, area 4, and primary somatosensory cortex, area 3b, are homogenous areas, with the major division lying between the two. Accumulating empirical and theoretical evidence, however, has begun to question the validity of the Brodmann map for various cortical areas. Here, we combined in vivo cortical myelin mapping with functional connectivity analyses and topographic mapping techniques to reassess the validity of the Brodmann map in human primary sensorimotor cortex. We provide empirical evidence that area 4 and area 3b are not homogenous, but are subdivided into distinct cortical fields, each representing a major body part (the hand and the face). Myelin reductions at the hand–face borders are cortical layer-specific, and coincide with intrinsic functional connectivity borders as defined using large-scale resting state analyses. Our data extend the Brodmann model in human sensorimotor cortex and suggest that body parts are an important organizing principle, similar to the distinction between sensory and motor processing.

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Language(s): eng - English
 Dates: 2017-01-092017-02-102017-07-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhx026
PMID: 28184419
PMC: PMC6248394
 Degree: -

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Project name : -
Grant ID : SAS-2015-LIN-LWC
Funding program : -
Funding organization : CBBS ScienceCampus - Leibniz Association
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Grant ID : -
Funding program : -
Funding organization : Helmholtz Alliance “ICEMED—Imaging and Curing Environmental Metabolic Diseases”
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Funding program : Marie Sklodowska-Curie International Reintegration Grant
Funding organization : European Commission (EC)
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Funding organization : Max Planck Institute for Human Cognitive and Brain Sciences and Deutsches Zentrum für Neurodegenerative Erkrankungen, Magdeburg
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Grant ID : -
Funding program : NIH Human Connectome Project
Funding organization : NIH Blueprint for Neuroscience Research
Project name : -
Grant ID : 1U54MH091657
Funding program : -
Funding organization : National Institutes of Health (NIH)

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 27 (7) Sequence Number: - Start / End Page: 3790 - 3805 Identifier: ISSN: 1047-3211
CoNE: /journals/resource/954925592440