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Free keywords:
COPPER-MEDIATED FLUORINATION; C-H FLUORINATION; REDUCTIVE ELIMINATION; ARYL FLUORIDES; BOND FORMATION; ELECTROPHILIC FLUORINATION; PD(III) COMPLEXES; PALLADIUM; DEOXYFLUORINATION; CONVERSION
Abstract:
A practical, palladium-catalyzed synthesis of aryl fluorides from arylboronic acid derivatives is presented. The reaction is operationally simple and amenable to multigram-scale synthesis. Evaluation of the reaction mechanism suggests a single-electron-transfer pathway, involving a Pd(III) intermediate that has been isolated and characterized.