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  Sublethal streptomycin concentrations and lytic bacteriophage together promote resistance evolution

Cairns, J., Becks, L., Jalasvuori, M., & Hiltunen, T. (2017). Sublethal streptomycin concentrations and lytic bacteriophage together promote resistance evolution. Philosophical Transactions of the Royal Society B: Biological Sciences, 372(1712): 20160040. doi:10.1098/rstb.2016.0040.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-3ACE-B Version Permalink: http://hdl.handle.net/21.11116/0000-0001-81D7-A
Genre: Journal Article

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Cairns, J.1, Author
Becks, L.1, Author              
Jalasvuori, M., Author
Hiltunen, T., Author
Affiliations:
1Research Group Community Dynamics, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445642              

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Free keywords: Bacteria (microorganisms); Pseudomonas fluorescens
 Abstract: Sub-minimum inhibiting concentrations (sub-MICs) of antibiotics frequently occur in natural environments owing to wide-spread antibiotic leakage by human action. Even though the concentrations are very low, these sub-MICs have recently been shown to alter bacterial populations by selecting for antibiotic resistance and increasing the rate of adaptive evolution. However, studies are lacking on how these effects reverberate into key ecological interactions, such as bacteria-phage interactions. Previously, co-selection of bacteria by phages and antibiotic concentrations exceeding MICs has been hypothesized to decrease the rate of resistance evolution because of fitness costs associated with resistance mutations. By contrast, here we show that sub-MICs of the antibiotic streptomycin (Sm) increased the rate of phage resistance evolution, aswell as causing extinction of the phage. Notably, Sm and the phage in combination also enhanced the evolution of Sm resistance compared with Sm alone. These observations demonstrate the potential of sub-MICs of antibiotics to impact key ecological interactions in microbial communities with evolutionary outcomes that can radically differ from those associated with high concentrations. Our findings also contribute to the understanding of ecological and evolutionary factors essential for the management of the antibiotic resistance problem. This article is part of the themed issue ‘Human influences on evolution, and the ecological and societal consequences’. © 2016 The Author(s) Published by the Royal Society. All rights reserved.

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 Dates: 2017
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1098/rstb.2016.0040
BibTex Citekey: Cairns2017
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Title: Philosophical Transactions of the Royal Society B: Biological Sciences
Source Genre: Journal
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Publ. Info: Royal Society of London
Pages: - Volume / Issue: 372 (1712) Sequence Number: 20160040 Start / End Page: - Identifier: -