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  Further investigation on the high-conductance ion channel of the inner membrane of mitochondria.

Sorgato, M. C., Moran, O., De Pinto, V., Keller, B. U., & Stühmer, W. (1989). Further investigation on the high-conductance ion channel of the inner membrane of mitochondria. Journal of Bioenergetics and Biomembranes, 21(4), 485-496. doi:10.1007/BF00762520.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-3C65-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-3C68-C
Genre: Journal Article

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2382411.pdf (Publisher version), 647KB
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Sorgato, M. C., Author
Moran, O., Author
De Pinto, V., Author
Keller, B. U.1, Author              
Stühmer, W.2, Author              
Affiliations:
1Research Group of Cellular Neurophysiology, MPI for biophysical chemistry, Max Planck Society, ou_578557              
2Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: By use of the patch-clamp technique, the inner membrane of mouse liver and heart mitochondria is shown to contain a highly conductive (around 100 pS in symmetrical 150 mM KCl) and voltage-dependent ion channel. This channel closely resembles that previously found in cuprizone-treated mouse liver inner mitochondrial membrane. The paper discusses the electrical properties of the channel and its possible physiological function. The reconstitution in giant liposomes of a partially purified ox heart inner membrane fraction containing the channel and the use of various inhibitors are also presented.

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Language(s): eng - English
 Dates: 1989-08
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1007/BF00762520
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Title: Journal of Bioenergetics and Biomembranes
Source Genre: Journal
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Pages: - Volume / Issue: 21 (4) Sequence Number: - Start / End Page: 485 - 496 Identifier: -