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  Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: Initial experience in patients with cerebral tumors.

Bruhn, H., Frahm, J., Gyngell, M., Merboldt, K. D., Hänicke, W., Sauter, R., et al. (1989). Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: Initial experience in patients with cerebral tumors. Radiology, 172(2), 541-548. doi:10.1148/radiology.172.2.2748837.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-3E2E-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-0FCD-1
Genre: Journal Article

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 Creators:
Bruhn, H.1, Author              
Frahm, J.1, Author              
Gyngell, M.L.1, Author              
Merboldt, K. D.1, Author              
Hänicke, W.1, Author              
Sauter, R., Author
Hamburger, C., Author
Affiliations:
1Research Group of Biomedical NMR, MPI for Biophysical Chemistry, Max Planck Society, ou_578633              

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 Abstract: A recently developed method for image-selected localized hydrogen-1 magnetic resonance (MR) spectroscopy was assessed in the differential diagnosis of nine primary and secondary cerebral tumors, including four gliomas, two meningiomas, one neurilemoma, one arachnoid cyst, and one metastasis of breast cancer. Well-resolved H-1 MR spectra of these tumors were obtained in vivo with a conventional 1.5-T whole-body MR imaging system. All tumor spectra were remarkably different from spectra from normal brain tissue. Spectra obtained from different tumors exhibited reproducible differences, while histologically similar tumors yielded characteristic spectra with only minor differences. The observed spectral alterations reflect variations in concentrations and relaxation times of the H-1 MR sensitive pool of free (mobile) metabolites within the tissues. In most cases, the concentrations of N-acetyl-aspartate and creatine/phosphocreatine are reduced below detectability, whereas choline-containing compounds are generally enhanced. The spectral differences between the tumors are mainly due to the differing concentrations of lipids, lactic acid, and carbohydrates. Localized H-1 MR spectroscopy may become an important clinical tool for the differentiation of tumors as well as for therapeutic control.

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Language(s): eng - English
 Dates: 1989-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1148/radiology.172.2.2748837
 Degree: -

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Title: Radiology
Source Genre: Journal
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Pages: - Volume / Issue: 172 (2) Sequence Number: - Start / End Page: 541 - 548 Identifier: -