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  The molecular hallmarks of epigenetic control

Allis, C. D., & Jenuwein, T. (2016). The molecular hallmarks of epigenetic control. Nature Reviews Genetics, 487-500. doi:doi: 10.1038/nrg.2016.59.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-A8B7-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-C2D9-B
Genre: Journal Article

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https://www.nature.com/articles/nrg.2016.59 (Publisher version)
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 Creators:
Allis, C. David1, Author
Jenuwein, Thomas2, Author              
Affiliations:
1The Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, USA, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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 Abstract: Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and associated mechanisms that alter chromatin in response to physiological or pathological signals have transformed our knowledge of epigenetics from a collection of curious biological phenomena to a functionally dissected research field. Here, we provide a personal perspective on the development of epigenetics, from its historical origins to what we define as 'the modern era of epigenetic research'. We primarily highlight key molecular mechanisms of and conceptual advances in epigenetic control that have changed our understanding of normal and perturbed development.

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Language(s): eng - English
 Dates: 2016-08
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: doi: 10.1038/nrg.2016.59
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Title: Nature Reviews Genetics
Source Genre: Journal
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Publ. Info: London, UK : Nature Pub. Group
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 487 - 500 Identifier: ISSN: 1471-0056
CoNE: https://pure.mpg.de/cone/journals/resource/110985821000939