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  Introduction of Fluorine and Fluorine-Containing Functional Groups

Liang, T., Neumann, C. N., & Ritter, T. (2013). Introduction of Fluorine and Fluorine-Containing Functional Groups. Angewandte Chemie International Edition, 52(32), 8214-8264. doi:10.1002/anie.201206566.

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 Urheber:
Liang, Theresa1, Autor
Neumann, Constanze N.1, Autor           
Ritter, Tobias1, Autor           
Affiliations:
1Department for Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA, ou_persistent22              

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Schlagwörter: CH functionalization; fluorine; homogeneous catalysis; transition metals; trifluoromethylation
 Zusammenfassung: Over the past decade, the most significant, conceptual advances in the field of fluorination were enabled most prominently by organo- and transition-metal catalysis. The most challenging transformation remains the formation of the parent C-F bond, primarily as a consequence of the high hydration energy of fluoride, strong metal-fluorine bonds, and highly polarized bonds to fluorine. Most fluorination reactions still lack generality, predictability, and cost-efficiency. Despite all current limitations, modern fluorination methods have made fluorinated molecules more readily available than ever before and have begun to have an impact on research areas that do not require large amounts of material, such as drug discovery and positron emission tomography. This Review gives a brief summary of conventional fluorination reactions, including those reactions that introduce fluorinated functional groups, and focuses on modern developments in the field.

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Sprache(n): eng - English
 Datum: 2012-08-142013-07-192013-08-05
 Publikationsstatus: Erschienen
 Seiten: 51
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/anie.201206566
 Art des Abschluß: -

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Titel: Angewandte Chemie International Edition
  Kurztitel : Angew. Chem., Int. Ed.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Weinheim : Wiley-VCH
Seiten: - Band / Heft: 52 (32) Artikelnummer: - Start- / Endseite: 8214 - 8264 Identifikator: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851