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  Integrin-mediated mechanotransduction

Sun, Z., Guo, S. S., & Fässler, R. (2016). Integrin-mediated mechanotransduction. The Journal of Cell Biology: JCB, 215(4), 445-456. doi:10.1083/jcb.201609037.

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This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license.
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 Creators:
Sun, Zhiqi1, Author              
Guo, Shengzhen S.1, Author              
Fässler, Reinhard1, Author              
Affiliations:
1Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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Free keywords: PANCREATIC DUCTAL ADENOCARCINOMA; FOCAL ADHESION MATURATION; CELL-MATRIX ADHESIONS; EXTRACELLULAR-MATRIX; MYOSIN-II; NASCENT ADHESIONS; FORCE TRANSMISSION; LIVING CELLS; MECHANICAL REGULATION; CYTOSKELETAL TENSIONCell Biology;
 Abstract: Cells can detect and react to the biophysical properties of the extracellular environment through integrin-based adhesion sites and adapt to the extracellular milieu in a process called mechanotransduction. At these adhesion sites, integrins connect the extracellular matrix (ECM) with the F-actin cytoskeleton and transduce mechanical forces generated by the actin retrograde flow and myosin II to the ECM through mechanosensitive focal adhesion proteins that are collectively termed the "molecular clutch." The transmission of forces across integrin-based adhesions establishes a mechanical reciprocity between the visco-elasticity of the ECM and the cellular tension. During mechanotransduction, force allosterically alters the functions of mechanosensitive proteins within adhesions to elicit biochemical signals that regulate both rapid responses in cellular mechanics and long-term changes in gene expression. Integrin-mediated mechanotransduction plays important roles in development and tissue homeostasis, and its dysregulation is often associated with diseases.

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Language(s): eng - English
 Dates: 2016
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000388690900005
DOI: 10.1083/jcb.201609037
 Degree: -

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Project name : grant agreement no. 322652
Grant ID : 322652
Funding program : -
Funding organization : European Research Council

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Title: The Journal of Cell Biology : JCB
  Other : J. Cell Biol.
Source Genre: Journal
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Publ. Info: New York, NY : Rockefeller Institute Press
Pages: - Volume / Issue: 215 (4) Sequence Number: - Start / End Page: 445 - 456 Identifier: ISSN: 0021-9525
CoNE: https://pure.mpg.de/cone/journals/resource/991042742946024