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  Intracellular magnesium blocks sodium outward currents in a voltage- and dose-dependent manner.

Pusch, M., Conti, F., & Stühmer, W. (1989). Intracellular magnesium blocks sodium outward currents in a voltage- and dose-dependent manner. Biophysical Journal, 55(6), 1267-1271. doi:10.1016/S0006-3495(89)82922-4.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-4760-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-4763-0
Genre: Journal Article

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2383763.pdf (Publisher version), 455KB
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Pusch, M.1, Author              
Conti, F., Author
Stühmer, W.1, Author              
Affiliations:
1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: Tail currents through Na+ channels have been measured in inside-out patches from Xenopus laevis oocytes injected with cDNA-derived mRNA coding for the rat brain type II Na+ channel. It is shown that intracellular Mg2+ blocks outward currents in a voltage- and dose-dependent manner with a half blocking concentration between 3 and 4 mM at 0 mV and a voltage dependence of e-fold per 49 mV.

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Language(s): eng - English
 Dates: 1989-06
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/S0006-3495(89)82922-4
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Title: Biophysical Journal
Source Genre: Journal
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Pages: - Volume / Issue: 55 (6) Sequence Number: - Start / End Page: 1267 - 1271 Identifier: -