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  Dyslexia risk gene relates to representation of sound in the auditory brainstem

Neef, N., Müller, B., Liebig, J., Schaadt, G., Grigutsch, M., Gunter, T. C., et al. (2017). Dyslexia risk gene relates to representation of sound in the auditory brainstem. Developmental Cognitive Neuroscience, 24, 63-71. doi:10.1016/j.dcn.2017.01.008.

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 Urheber:
Neef, Nicole1, Autor           
Müller, Bent2, Autor
Liebig, Johanna1, Autor           
Schaadt, Gesa1, 3, Autor           
Grigutsch, Maren1, Autor           
Gunter, Thomas C.1, Autor           
Wilcke, Arndt2, Autor
Kirsten, Holger2, 4, Autor
Skeide, Michael A.1, Autor           
Kraft, Indra1, Autor           
Kraus, Nina5, Autor
Frank, Emmrich2, Autor
Brauer, Jens1, Autor           
Boltze, Johannes2, 6, Autor
Friederici, Angela D.1, Autor           
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Department of Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany, ou_persistent22              
3Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Auditory Neuroscience Laboratory, Northwestern University, Evanston, IL, USA, ou_persistent22              
6Department of Medical Cell Technology, Fraunhofer Institute for Marine Biotechnology, Lübeck, Germany, ou_persistent22              

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Schlagwörter: Developmental dyslexia; KIAA0319; DCDC2; Brainstem responses; Sound processing; Genetic risk
 Zusammenfassung: Dyslexia is a reading disorder with strong associations with KIAA0319 and DCDC2. Both genes play a functional role in spike time precision of neurons. Strikingly, poor readers show an imprecise encoding of fast transients of speech in the auditory brainstem. Whether dyslexia risk genes are related to the quality of sound encoding in the auditory brainstem remains to be investigated. Here, we quantified the response consistency of speech-evoked brainstem responses to the acoustically presented syllable [da] in 159 genotyped, literate and preliterate children. When controlling for age, sex, familial risk and intelligence, partial correlation analyses associated a higher dyslexia risk loading with KIAA0319 with noisier responses. In contrast, a higher risk loading with DCDC2 was associated with a trend towards more stable responses. These results suggest that unstable representation of sound, and thus, reduced neural discrimination ability of stop consonants, occurred in genotypes carrying a higher amount of KIAA0319 risk alleles. Current data provide the first evidence that the dyslexia-associated gene KIAA0319 can alter brainstem responses and impair phoneme processing in the auditory brainstem. This brain-gene relationship provides insight into the complex relationships between phenotype and genotype thereby improving the understanding of the dyslexia-inherent complex multifactorial condition.

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Sprache(n): eng - English
 Datum: 2017-01-152016-09-262017-01-152017-01-172017-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.dcn.2017.01.008
PMID: 28182973
Anderer: Epub 2017
 Art des Abschluß: -

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Projektname : Legascreen
Grant ID : M.FE.A.NEPF0001
Förderprogramm : -
Förderorganisation : Fraunhofer Society and Max Planck Society
Projektname : -
Grant ID : -
Förderprogramm : Leipzig Interdisciplinary Research Cluster of Genetic Factors, Clinical Phenotypes and Environment
Förderorganisation : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig

Quelle 1

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Titel: Developmental Cognitive Neuroscience
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Amsterdam : Elsevier
Seiten: - Band / Heft: 24 Artikelnummer: - Start- / Endseite: 63 - 71 Identifikator: ISSN: 1878-9293
CoNE: https://pure.mpg.de/cone/journals/resource/1878-9293