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  Dyslexia risk gene relates to representation of sound in the auditory brainstem

Neef, N., Müller, B., Liebig, J., Schaadt, G., Grigutsch, M., Gunter, T. C., et al. (2017). Dyslexia risk gene relates to representation of sound in the auditory brainstem. Developmental Cognitive Neuroscience, 24, 63-71. doi:10.1016/j.dcn.2017.01.008.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-47A3-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C520-A
Genre: Journal Article

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 Creators:
Neef, Nicole1, Author              
Müller, Bent2, Author
Liebig, Johanna1, Author              
Schaadt, Gesa1, 3, Author              
Grigutsch, Maren1, Author              
Gunter, Thomas C.1, Author              
Wilcke, Arndt2, Author
Kirsten, Holger2, 4, Author
Skeide, Michael A.1, Author              
Kraft, Indra1, Author              
Kraus, Nina5, Author
Frank, Emmrich2, Author
Brauer, Jens1, Author              
Boltze, Johannes2, 6, Author
Friederici, Angela D.1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Department of Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany, ou_persistent22              
3Department of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Auditory Neuroscience Laboratory, Northwestern University, Evanston, IL, USA, ou_persistent22              
6Department of Medical Cell Technology, Fraunhofer Institute for Marine Biotechnology, Lübeck, Germany, ou_persistent22              

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Free keywords: Developmental dyslexia; KIAA0319; DCDC2; Brainstem responses; Sound processing; Genetic risk
 Abstract: Dyslexia is a reading disorder with strong associations with KIAA0319 and DCDC2. Both genes play a functional role in spike time precision of neurons. Strikingly, poor readers show an imprecise encoding of fast transients of speech in the auditory brainstem. Whether dyslexia risk genes are related to the quality of sound encoding in the auditory brainstem remains to be investigated. Here, we quantified the response consistency of speech-evoked brainstem responses to the acoustically presented syllable [da] in 159 genotyped, literate and preliterate children. When controlling for age, sex, familial risk and intelligence, partial correlation analyses associated a higher dyslexia risk loading with KIAA0319 with noisier responses. In contrast, a higher risk loading with DCDC2 was associated with a trend towards more stable responses. These results suggest that unstable representation of sound, and thus, reduced neural discrimination ability of stop consonants, occurred in genotypes carrying a higher amount of KIAA0319 risk alleles. Current data provide the first evidence that the dyslexia-associated gene KIAA0319 can alter brainstem responses and impair phoneme processing in the auditory brainstem. This brain-gene relationship provides insight into the complex relationships between phenotype and genotype thereby improving the understanding of the dyslexia-inherent complex multifactorial condition.

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Language(s): eng - English
 Dates: 2017-01-152016-09-262017-01-152017-01-172017-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.dcn.2017.01.008
PMID: 28182973
Other: Epub 2017
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Project name : Legascreen
Grant ID : M.FE.A.NEPF0001
Funding program : -
Funding organization : Fraunhofer Society and Max Planck Society
Project name : -
Grant ID : -
Funding program : Leipzig Interdisciplinary Research Cluster of Genetic Factors, Clinical Phenotypes and Environment
Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig

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Title: Developmental Cognitive Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 24 Sequence Number: - Start / End Page: 63 - 71 Identifier: ISSN: 1878-9293
CoNE: /journals/resource/1878-9293