English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Medial prefrontal-hippocampal connectivity during emotional memory encoding predicts individual differences in the loss of associative memory specificity

Berkers, R., Klumpers, F., & Fernandez, G. (2016). Medial prefrontal-hippocampal connectivity during emotional memory encoding predicts individual differences in the loss of associative memory specificity. Neurobiology of Learning and Memory, 134(A), 44-54. doi:10.1016/j.nlm.2016.01.016.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-48E6-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1C0D-1
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Berkers, Ruud1, Author              
Klumpers, Floris1, Author
Fernandez, Guillen1, Author
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              

Content

show
hide
Free keywords: Emotional memory; Encoding; Hippocampus; Medial prefrontal cortex; Memory specificity; fMRI
 Abstract: Emotionally charged items are often remembered better, whereas a paradoxical loss of specificity is found for associative emotional information (specific memory). The balance between specific and generalized emotional memories appears to show large individual differences, potentially related to differences in (the risk for) affective disorders that are characterized by 'overgeneralized' emotional memories. Here, we investigate the neural underpinnings of individual differences in emotional associative memory. A large group of healthy male participants were scanned while encoding associations of face-photographs and written occupational identities that were of either neutral ('driver') or negative ('murderer') valence. Subsequently, memory was tested by prompting participants to retrieve the occupational identities corresponding to each face. Whereas in both valence categories a similar amount of faces was labeled correctly with 'neutral' and 'negative' identities, (gist memory), specific associations were found to be less accurately remembered when the occupational identity was negative compared to neutral (specific memory). This pattern of results suggests reduced memory specificity for associations containing a negatively valenced component. The encoding of these negative associations was paired with a selective increase in medial prefrontal cortex activity and medial prefrontal-hippocampal connectivity. Individual differences in valence-specific neural connectivity were predictive of valence-specific reduction of memory specificity. The relationship between loss of emotional memory specificity and medial prefrontal-hippocampal connectivity is in line with the hypothesized role of a medial prefrontal-hippocampal circuit in regulating memory specificity, and warrants further investigations in individuals displaying 'overgeneralized' emotional memories.

Details

show
hide
Language(s): eng - English
 Dates: 2016-01-252015-06-232016-01-312016-02-082016-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.nlm.2016.01.016
PMID: 26868478
Other: Epub 2016
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Neurobiology of Learning and Memory
  Other : Neurobiol. Learn. Mem.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, Fla. : Academic Press
Pages: - Volume / Issue: 134 (A) Sequence Number: - Start / End Page: 44 - 54 Identifier: ISSN: 1074-7427
CoNE: https://pure.mpg.de/cone/journals/resource/954926963939