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  Increased zinc accumulation in mineralized osteosarcoma tissue measured by confocal synchrotron radiation micro X-ray fluorescence analysis

Rauwolf, M., Pemmer, B., Roschger, A., Turyanskaya, A., Smolek, S., Maderitsch, A., et al. (2017). Increased zinc accumulation in mineralized osteosarcoma tissue measured by confocal synchrotron radiation micro X-ray fluorescence analysis. X-Ray Spectrometry, 46(1), 56-92. doi:10.1002/xrs.2727.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-4ABB-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-5FBC-3
Genre: Journal Article

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 Creators:
Rauwolf, Mirjam, Author
Pemmer, Bernhard, Author
Roschger, Andreas1, Author              
Turyanskaya, Anna, Author
Smolek, Stephan, Author
Maderitsch, Angelika, Author
Hischenhuber, Peter, Author
Foelser, Martin, Author
Simon, Rolf, Author
Lang, Susanna, Author
Puchner, Stephan E., Author
Windhager, Reinhard, Author
Klaushofer, Klaus, Author
Wobrauschek, Peter, Author
Hofstaetter, Jochen G., Author
Roschger, Paul, Author
Streli, Christina, Author
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1external organisation, ou_persistent22              

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Free keywords: Open Access
 Abstract: Abnormal tissue levels of certain trace elements such as zinc (Zn) were reported in various types of cancer. Little is known about the role of Zn in osteosarcoma. Using confocal synchrotron radiation micro X-ray fluorescence analysis, we characterized the spatial distribution of Zn in high-grade sclerosing osteosarcoma of nine patients (four women/five men; seven knee/one humerus/one femur) following chemotherapy and wide surgical resection. Levels were compared with adjacent normal tissue. Quantitative backscattered electron imaging as well as histological examinations was also performed. On average, the ratio of medians of Zn count rates (normalized to calcium) in mineralized tumor tissue was about six times higher than in normal tissue. There was no difference in Zn levels between tumor fraction areas with a low fraction and a high fraction of mineralized tissue, which were clearly depicted using quantitative backscattered electron imaging. Moreover, we found no correlation between the Zn values and the type of tumor regression according to the Salzer-Kuntschik grading. The underlying mechanism of Zn accumulation remains unclear. Given the emerging data on the role of trace elements in other types of cancer, our novel results warrant further studies on the role of trace elements in bone cancer. Copyright © 2016 The Authors. X-Ray Spectrometry published by John Wiley & Sons Ltd.

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 Dates: 2016-12-212017
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/xrs.2727
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Title: X-Ray Spectrometry
  Other : X-Ray Spectrom.
Source Genre: Journal
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Publ. Info: London : Wiley
Pages: - Volume / Issue: 46 (1) Sequence Number: - Start / End Page: 56 - 92 Identifier: ISSN: 0049-8246