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  Low somatic sodium conductance enhances action potential precision in time-coding auditory neurons.

Yang, Y., Ramamurthy, B., Neef, A., & Xu-Friedman, M. A. (2016). Low somatic sodium conductance enhances action potential precision in time-coding auditory neurons. Journal of Neuroscience, 36(47), 11999-12009. doi:10.1523/JNEUROSCI.1475-16.2016.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-4ADD-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-414A-C
Genre: Journal Article

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http://www.jneurosci.org/content/36/47/11999 (Publisher version)
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 Creators:
Yang, Y., Author
Ramamurthy, B., Author
Neef, Andreas1, Author              
Xu-Friedman, M. A., Author
Affiliations:
1Research Group Theoretical Neurophysics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063289              

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Free keywords: Cochlear nucleus; Dynamic clamp; Sodium channels; Spike initiation; Synaptic transmission; Time coding
 Abstract: Auditory nerve fibers encode sounds in the precise timing of action potentials (APs), which is used for such computations as sound localization. Timing information is relayed through several cell types in the auditory brainstem that share an unusual property: their APs are not overshooting, suggesting that the cells have very low somatic sodium conductance (g(Na)). However, it is not clear how g(Na) influences temporal precision. We addressed this by comparing bushy cells (BCs) in the mouse cochlear nucleus with T-stellate cells (SCs), which do have normal overshooting APs. BCs play a central role in both relaying and refining precise timing information from the auditory nerve, whereas SCs discard precise timing information and encode the envelope of sound amplitude. Nucleated-patch recording at near physiological temperature indicated that the Na current density was 62% lower in BCs, and the voltage dependence of gNa inactivation was 13 mV hyperpolarized compared with SCs. We endowed BCs with SC-like g(Na) using two-electrode dynamic clamp and found that synaptic activity at physiologically relevant rates elicited APs with significantly lower probability, through increased activation of delayed rectifier channels. In addition, for two near-simultaneous synaptic inputs, the window of coincidence detection widened significantly with increasing gNa, indicating that refinement of temporal information by BCs is degraded by g(Na). Thus, reduced somatic gNa appears to be an adaption for enhancing fidelity and precision in time-coding neurons.

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Language(s): eng - English
 Dates: 2016-11-23
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1523/JNEUROSCI.1475-16.2016
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Title: Journal of Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 36 (47) Sequence Number: - Start / End Page: 11999 - 12009 Identifier: -