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  Influence of epidermal growth factor on long-term potentiation in the hippocampal slice.

Terlau, H., & Seifert, W. (1989). Influence of epidermal growth factor on long-term potentiation in the hippocampal slice. Brain Research, 484(1-2), 352-356. doi:10.1016/0006-8993(89)90380-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-4BE1-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-4BE6-6
Genre: Journal Article

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2385076.pdf (Publisher version), 378KB
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 Creators:
Terlau, H.1, Author              
Seifert, W.1, Author              
Affiliations:
1Abteilung Neurobiologie, MPI for biophysical chemistry, Max Planck Society, ou_578620              

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 Abstract: Rat hippocampal slices were perfused with epidermal growth factor (EGF) at a concentration of 10−8 M. EGF is a well known mitogen which exhibits neurotrophic action on neurons of the CNS. During extra- and intracellular recordings in the pyramidal cell body layer of the CA1-region no influence of EGF on evoked potentials was seen if single-pulse or paired-pulse stimulation was used. Furthermore EGF has no influence on the resting membrane potential of the cells investigated. However after tetanic stimulation a significant increase in the magnitude of long-term potentiation was observed. Therefore it is concluded, that EGF might be involved in modulation of neuronal plasticity.

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Language(s): eng - English
 Dates: 1989-04-10
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/0006-8993(89)90380-6
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Title: Brain Research
Source Genre: Journal
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Pages: - Volume / Issue: 484 (1-2) Sequence Number: - Start / End Page: 352 - 356 Identifier: -